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Dose-Dependent Effect of Nerve Growth Factor Mimetic GK-2 in a Wistar Rat Diabetes Model

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Pharmaceutical Chemistry Journal Aims and scope

Experimental results for the new nerve growth factor (NGF) mimetic GK-2 [bis-(N-monosuccinyl-L-glutamyl-L-lysine)hexamethylenediamide] administered perorally toWistar rats in a streptozotocin-induced type 2 diabetes mellitus model are reported. The antihyperglycemic activity of GK-2 was determined in a dose range from 1 to 10 mg/kg. The most pronounced effect was observed at doses of 2.5 and 5 mg/kg. GK-2 was also found to reduce the severity of polydipsia and polyphagia and to produce a positive effect on the body-weight dynamics of diabetic animals. The dose dependence of GK-2 effects was described by a bell-shaped curve typical of regulatory peptides with various chemical structures. The ten-fold greater width of the dose–activity curve of the drug observed in this work combined with its high safety suggests that a satisfactory therapeutic index for GK-2 as a potential antidiabetic drug for peroral administration can be expected.

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Authors and Affiliations

  1. V. V. Zakusov Institute of Pharmacology, 8 Baltiiskaya St, Moscow, 125315, Russia

    S. V. Ivanov, R. U. Ostrovskaya, T. A. Gudasheva & S. B. Seredenin

Authors
  1. S. V. Ivanov
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  2. R. U. Ostrovskaya
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  3. T. A. Gudasheva
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  4. S. B. Seredenin
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Corresponding author

Correspondence to S. V. Ivanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 4, pp. 11 – 15, April, 2021.

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Ivanov, S.V., Ostrovskaya, R.U., Gudasheva, T.A. et al. Dose-Dependent Effect of Nerve Growth Factor Mimetic GK-2 in a Wistar Rat Diabetes Model. Pharm Chem J 55, 323–327 (2021). https://doi.org/10.1007/s11094-021-02420-1

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  • DOI: https://doi.org/10.1007/s11094-021-02420-1

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