Skip to main content
Log in

Effect of Exhaustive Training or Forced Immobilization on Physiological Condition and Main Metabolic and Stress Markers of Wistar Male Rats

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

For correct and reliable experimental in vivo assessment of antistress effect of various bioactive substances, appropriate biomodels reproducing stress and organism response to stress in laboratory animals should be chosen. We chose treadmill test for simulating exhaustive physical load and forced immobilization accompanied by disorders of physiological and psychological condition. Verification of the models used indicates their wide applicability for testing certain biological manifestations under reproduced stress exposure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ermolaeva EN. Changes in the lipid composition of blood under the influence of a single submaximal exercise capacity (experimental research). Saratov. Nauch.-Med. Zh. 2015;11(2):123-125. Russian.

    Google Scholar 

  2. Koplik EV, Pertsov SS, Kalinichenko LS. Effect of interleukin-1β on peripheral blood leukocytes in rats with various behavioral characteristics during acute stress. Bull. Exp. Biol. Med. 2014;156(4):435-440. doi: https://doi.org/10.1007/s10517-014-2368-5

    Article  CAS  PubMed  Google Scholar 

  3. Sidorova AA, Kartsova LA. The chromatographic and electrophoretic determination of catecholamines, metanephrines and 3,4-dihydroxyphenylalanine in urine and blood plasma. Sorb. Khromatorgraph. Processy. 2009;9(6):774-782. Russian.

    Google Scholar 

  4. Sidorova YS, Sarkisyan VА, Petrov NA, Kochetkova AA, Mazo VK. Experimental Evaluation of the Efficiency of Lipid Module Enriched with Docosahexaenoic Acid and Astaxantin. Bull. Exp. Biol. Med. 2017;163(5):691-694. doi: https://doi.org/10.1007/s10517-017-3880-1

    Article  CAS  PubMed  Google Scholar 

  5. Handbook. Physiological, Biochemical, and Biometric Normal Values for Experimental Animals. Makarov VG and makarova MN, eds. St. Petersburg, 2013. Russian.

  6. Castanheira L, Ferreira MF, Sebastião AM, Telles-Correia D. Anxiety Assessment in Pre-clinical Tests and in Clinical Trials: A Critical Review. Curr. Top. Med. Chem. 2018;18(19):1656-1676. doi: https://doi.org/10.2174/1568026618666181115102518

    Article  CAS  PubMed  Google Scholar 

  7. de Andrade Soares R, de Oliveira BC, de Bem GF, de Menezes MP, Romão MH, Santos IB, da Costa CA, de Carvalho LCDRM, Nascimento ALR, de Carvalho JJ, Ognibene DT, de Moura RS, Resende AC. Açaí (Euterpe oleracea Mart.) seed extract improves aerobic exercise performance in rats. Food Res. Int. 2020;136:109549. doi: https://doi.org/10.1016/j.foodres.2020.109549]

  8. Haddadi H, Rajaei Z, Alaei H, Shahidani S. Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson’s disease. Arq. Neuropsiquiatr. 2018;76(2):71-77. doi: https://doi.org/10.1590/0004-282X20170193

    Article  PubMed  Google Scholar 

  9. Ruiz-Iglesias P, Estruel-Amades S, Camps-Bossacoma M, Massot-Cladera M, Castell M, Pérez-Cano FJ. Alterations in the mucosal immune system by a chronic exhausting exercise in Wistar rats. Sci. Rep. 2020;10(1):17950. doi: https://doi.org/10.1038/s41598-020-74837-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Sahin Z, Ozkurkculer A, Kalkan OF, Ozkaya A, Koc A, Koca RO, Solak H, Gormus ZIS, Kutlu S. Chronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats. Int. J. Vitam. Nutr. Res. 2020:1-8. doi: https://doi.org/10.1024/0300-9831/a000682

  11. Xu X, Ding Y, Yang Y, Gao Y, Sun Q, Liu J, Yang X, Wang J, Zhang J. β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice. Nutrients. 2018;10(7):858. doi: https://doi.org/10.3390/nu10070858

    Article  CAS  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yu. S. Sidorova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 3, pp. 290-295, March, 2021

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sidorova, Y.S., Petrov, N.A., Zorin, S.N. et al. Effect of Exhaustive Training or Forced Immobilization on Physiological Condition and Main Metabolic and Stress Markers of Wistar Male Rats. Bull Exp Biol Med 171, 312–316 (2021). https://doi.org/10.1007/s10517-021-05218-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-021-05218-z

Key Words

Navigation