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Ultrastructure of Endothelial Cells of Myocardial Capillaries in Burn Septicotoxemia

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied ultrastructure and vesicular structures in endothelial cells of myocardial micro-vessels in burn patients. Electron microscopy revealed a significant decrease in volume density of vesicular structures in the endotheliocytes of myocardial capillaries in patients with burn septicotoxemia. The observed structural signs of endothelial dysfunction revealed in this category of patients can be a promising area for further research and for the development of methods of pathogenetic correction of myocardial disorders in the case of burn injury.

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References

  1. Elkin SR, Lakoduk AM, Schmid SL. Endocytic pathways and endosomal trafficking: a primer. Wien Med. Wochenschr. 2016;166(7-8):196-204. doi: https://doi.org/10.1007/s10354-016-0432-7

    Article  PubMed  PubMed Central  Google Scholar 

  2. Farshadzadeh Z, Khosravi AD, Alavi SM, Parhizgari N, Hoveizavi H. Spread of extended-spectrum β-lactamase genes of blaOXA-10, blaPER-1 and blaCTX-M in Pseudo monas aeruginosa strains isolated from burn patients. Burns. 2014;40(8):1575-1580. doi: https://doi.org/10.1016/j.burns.2014.02.008

    Article  PubMed  Google Scholar 

  3. Guillory AN, Clayton RP, Herndon DN, Finnerty CC. Cardiovascular Dysfunction Following Burn Injury: What We Have Learned from Rat and Mouse Models. Int. J. Mol. Sci. 2016;17(1):53. doi: https://doi.org/10.3390/ijms17010053

    Article  CAS  PubMed Central  Google Scholar 

  4. Guillory AN, Clayton RP, Prasai A, El Ayadi A, Herndon DN, Finnerty CC. Biventricular differences in β-adrenergic receptor signaling following burn injury. PLoS One. 2017;12(12):e0189527. doi: https://doi.org/10.1371/journal.pone.0189527

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Horton JW. A model of myocardial inflammation and dysfunction in burn complicated by sepsis. Shock. 2007;28(3):326-333. doi: https://doi.org/10.1097/01.shk.0000238064.54332.c8

    Article  CAS  PubMed  Google Scholar 

  6. Maan ZN, Frew Q, Din AH, Unluer Z, Smailes S, Philp B, El-Muttardi N, Dziewulski P. Burns ITU admissions: length of stay in specific levels of care for adult and paediatric patients. Burns. 2014;40(8):1458-1462. doi: https://doi.org/10.1016/j.burns.2014.07.026

    Article  PubMed  Google Scholar 

  7. Niederbichler AD, Hoesel LM, Ipaktchi K, Olivarez L, Erdmann M, Vogt PM, Su GL, Arbabi S, Westfall MV, Wang SC, Hemmila MR. Burn-induced heart failure: lipopolysaccharide binding protein improves burn and endotoxin-induced cardiac contractility deficits. J. Surg. Res. 2011;165(1):128-135. doi: https://doi.org/10.1016/j.jss.2009.06.012

    Article  CAS  PubMed  Google Scholar 

  8. Parkar NS, Akpa BS, Nitsche LC, Wedgewood LE, Place AT, Sverdlov MS, Chaga O, Minshall RD. Vesicle formation and endocytosis: function, machinery, mechanisms, and modeling. Antioxid. Redox Signal. 2009;11(6):1301-1312. doi: https://doi.org/10.1089/ars.2008.2397

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Schubert W, Frank PG, Woodman SE, Hyogo H, Cohen DE, Chow CW, Lisanti MP. Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J. Biol. Chem. 2002;277(42):40 091-40 098. doi: https://doi.org/10.1074/jbc.M205948200

  10. Simionescu M, Popov D, Sima A. Endothelial transcytosis in health and disease. Cell Tissue Res. 2009;335(1):27-40. doi: https://doi.org/10.1007/s00441-008-0688-3

    Article  PubMed  Google Scholar 

  11. Sohn J, Brick RM, Tuan RS. From embryonic development to human diseases: The functional role of caveolae/caveolin. Birth Defects Res. C Embryo Today. 2016;108(1):45-64. doi: https://doi.org/10.1002/bdrc.21121

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Weber J, McManus A; Nursing Committee of the International Society for Burn Injuries. Infection control in burn patients. Burns. 2004;30(8):A16-A24. doi: https://doi.org/10.1016/j.burns.2004.08.003

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    Yu. S. Taskaeva & N. P. Bgatova

  2. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    S. V. Savchenko, A. S. Grebenshchikova, N. G. Oshchepkova & E. V. Kuznetsov

Authors
  1. Yu. S. Taskaeva
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  2. N. P. Bgatova
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  3. S. V. Savchenko
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  4. A. S. Grebenshchikova
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  5. N. G. Oshchepkova
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  6. E. V. Kuznetsov
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Corresponding author

Correspondence to S. V. Savchenko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 3, pp. 379-385, March, 2021

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Taskaeva, Y.S., Bgatova, N.P., Savchenko, S.V. et al. Ultrastructure of Endothelial Cells of Myocardial Capillaries in Burn Septicotoxemia. Bull Exp Biol Med 171, 393–398 (2021). https://doi.org/10.1007/s10517-021-05235-y

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  • DOI: https://doi.org/10.1007/s10517-021-05235-y

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