The hypoglycemic activity of glycyrrhizic acid (GA, I), its trisodium (II) and sodium-dilithium salts (III), and a conjugate with L-methionine methyl ester (IV) was studied using an alloxan diabetes model after peroral administration to male Wistar rats. It was found that GA and its conjugate IV at a dose of 100 mg/kg exhibited hypoglycemic activity and reduced the blood glucose content of the animals by 35.5 and 42.6%, respectively, after 120 min. GA conjugate IV had low toxicity and hypoglycemic activity superior to those of GA and acarbose.
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ACKNOWLEDGMENTS
The work was performed on State Task Topics AAAAA20-120012090026-9 and AAAA-A20-120012090029-0 and used equipment at the Khimiya CUC.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 4, pp. 29 – 33, April, 2021.
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Baltina, L.A., Sapozhnikova, T.A., Gabdrakhmanova, S.F. et al. Hypoglycemic Activity of Glycyrrhizic Acid and Some of its Derivatives in the Alloxan Diabetes Model in Rats. Pharm Chem J 55, 340–344 (2021). https://doi.org/10.1007/s11094-021-02424-x
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DOI: https://doi.org/10.1007/s11094-021-02424-x