Abstract
Allergy to Galactose-Alpha-1,3-Galactose is an allergy to mammalian proteins, that are present on the surface of standard bioprosthestic valves, and could result in a catastrophic allergic reaction or may cause early deterioration of the bioprostheses. Aortic homograft is an acceptable alternative to standard prosthetic valves (biological and mechanical) to avoid a potential allergic manifestation and the need for definitive oral anticoagulation. We report the implantation of an aortic homograft in a patient with an aortic stenosis who presents a documented AlphaGal allergy.
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Mozzicato SM, Tripathi A, Posthumus JB, Platts-Mills TAE, Commins SP. Porcine or bovine valve replacement in three patients with IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose. J Allergy Clin Immunol Pract. 2014;2(5):637–8.
Hawkins RB, Frischtak HL, Kron IL, Ghanta RK. Premature bioprosthetic aortic valve degeneration associated with allergy to Galactose-Alpha-1,3-Galactose. J Card Surg. 2016;31(7):446–8.
Baumgartner H, Falk V, Bax JJ, Holm PJ, Iung B, Lancellotti P, et al. 2017 ECS/EATCS Guidelines for the management of valvular heart disease. The Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2017;00:1–53.
Burk CM, Beitia R, Lund PK, Dellon ES. High Rate of galactose-alpha- 1,3-galactose sensitization in both eosinophilic esophagitis and patients undergoing upper endoscopy. Dis Esophagus. 2016;29(6):558–62.
Konacki KZ, Bohle B, Blumer R, Hoetzenecher W, Roth G, Moser B, et al. Alpha-Gal on bioprotheses: xenograft immune response in cardiac surgery. Eur J Clin Invest. 2005;35(1):17–23.
Mangold A, Szerafin T, Hoetzenecker K, Hacker S, Lichtenauer M, Niederpold T, et al. Alpha-gal speficic igg immune response afer implantation of bioprotheses. Thorac Cardiov Surg. 2009;57:191–5.
Bloch O, Golde P, Dohmen PM, Posner S, Konertz W, Erdbrügger W. Immune response in patients receiving a bioprosthetic heart valve: lack of response with decellularized valves. Tissue Eng Part A. 2011;17(19–20):2399–405.
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Dang Van, S., Fouquet, O., Jeanneteau, A. et al. Aortic homograft for aortic valve replacement in patient with Alpha-Gal allergy. Gen Thorac Cardiovasc Surg 69, 1499–1501 (2021). https://doi.org/10.1007/s11748-021-01684-4
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DOI: https://doi.org/10.1007/s11748-021-01684-4