By engaging Toll-like receptor 2, translationally controlled tumor protein (TCTP) released from necrotic tumor cells can switch on an immunosuppressive network of monocytic and polymorphonuclear myeloid-derived suppressor cells to block antitumor immunity.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8+ T cells in hepatocellular carcinoma
Communications Biology Open Access 30 January 2023
-
Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis
Signal Transduction and Targeted Therapy Open Access 23 August 2022
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. & Kroemer, G. Nat. Rev. Immunol. 17, 97–111 (2017).
Ma, Y., Pitt, J. M., Li, Q. & Yang, H. Immunol. Rev. 280, 194–206 (2017).
Hangai, S. et al. Nat Immunol. https://doi.org/10.1038/s41590-021-00967-5 (2021).
Yee, P. P. et al. Nat. Commun. 11, 5424 (2020).
Yatim, N., Cullen, S. & Albert, M. L. Nat. Rev. Immunol. 17, 262–275 (2017).
Ahrens, S. et al. Immunity 36, 635–645 (2012).
Hangai, S. et al. Proc. Natl Acad. Sci. USA 113, 3844–3849 (2016).
Seifert, L. et al. Nature 532, 245–249 (2016).
Bommer, U.-A. Results Probl. Cell Differ. 64, 69–126 (2017).
Bommer, U.-A. et al. Cell Commun. Signal. 15, 9 (2017).
Sterle, H. A. et al. Br. J. Cancer 120, 128–138 (2019).
Yang, X. D. et al. Nat. Med. 17, 87–95 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Ma, Y. Tpt1 the balance toward immunosuppression upon cell death. Nat Immunol 22, 940–942 (2021). https://doi.org/10.1038/s41590-021-00986-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-021-00986-2
This article is cited by
-
Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8+ T cells in hepatocellular carcinoma
Communications Biology (2023)
-
Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis
Signal Transduction and Targeted Therapy (2022)