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Design, Synthesis, and Antimicrobial Activity of Novel Fluorine-Containing Imidazolones

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Abstract

A simple synthetic protocol have been developed for the preparation of novel N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl)-N′-phenylthiourea derivatives by the reaction of 4-benzylidene-2-phenyl-4,5-dihydro-1,3-oxazol-5-ones with N-(3-chloro-4-fluorophenyl)- and N-[3-(trifluoromethyl)phenyl)hydrazinecarbothioamides. The synthesized imidazolones have been characterized by using different spectroscopic techniques and evaluated for their antimicrobial activity against some bacterial and fungal strains. Imidazolone derivatives containing 2-nitrobenzylidene and 4-methoxybenzylidene substituents were found to be potent against fungal strains Candida albicans and Aspergillus clavatus..

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Funding

Prof. N.C. Desai thanks the UGC for awarding BSR faculty fellowship-2019 (no. F18-1/2011) and financial assistant. The authors also thank the University Grants Commission and Department of Science and Technology (New Delhi) for financial support under the NON-SAP and DST-FIST programs, respectively.

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Authors and Affiliations

  1. Division of Medicinal Chemistry, Department of Chemistry, Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364002, Bhavnagar, India

    N. C. Desai & H. K. Mehta

  2. Reliance Rasayan R&D Centre, 382330, Ahmedabad, Gujarat, India

    K. R. Wadekar

  3. Jawaharlal Nehru University, 110067, New Delhi, India

    U. P. Pandit

Authors
  1. N. C. Desai
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  2. K. R. Wadekar
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  3. H. K. Mehta
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  4. U. P. Pandit
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Correspondence to N. C. Desai.

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Desai, N.C., Wadekar, K.R., Mehta, H.K. et al. Design, Synthesis, and Antimicrobial Activity of Novel Fluorine-Containing Imidazolones. Russ J Org Chem 57, 976–985 (2021). https://doi.org/10.1134/S1070428021060142

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