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Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer’s Disease

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Bulletin of Experimental Biology and Medicine Aims and scope

Neuroprotective peptides are promising candidate molecules for the treatment of Alzheimer’s disease (AD). Oral application of KED (Lys-Glu-Asp) improved memory and attention in elderly individuals with functional CNS disorders. Peptide KED also restores synaptic plasticity in in vitro model of AD. This review is focused on the analysis of the influence of KED peptide on the expression of genes and synthesis of proteins regulating apoptosis, aging, neurogenesis, and involved in AD pathogenesis. Analysis of published reports and our experimental findings suggests that KED regulates the expression of genes of cell aging and apoptosis (р16, р21), genes (NES, GAP43) and proteins (nestin, GAP43) of the neuronal differentiation, and genes involved in AD pathogenesis (SUMO, APOE, and IGF1). The study the effectiveness of neuroprotective peptide KED in animal models of AD seems to be very important.

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Authors and Affiliations

  1. Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    V. Kh. Khavinson, N. S. Lin’kova & R. S. Umnov

  2. Department of Therapy, Geriatrics, and Anti-Aging Medicine, Academy of Postgraduate Education, Federal Research Clinical Centre of Federal Medical-Biological Agency of Russia, Moscow, Russia

    N. S. Lin’kova

  3. Laboratory “Problems of Aging”, Belgorod State National Research University, Belgorod, Russia

    N. S. Lin’kova

Authors
  1. V. Kh. Khavinson
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  2. N. S. Lin’kova
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  3. R. S. Umnov
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Corresponding author

Correspondence to N. S. Lin’kova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 2, pp. 150-154, February, 2021

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Khavinson, V.K., Lin’kova, N.S. & Umnov, R.S. Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer’s Disease. Bull Exp Biol Med 171, 190–193 (2021). https://doi.org/10.1007/s10517-021-05192-6

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  • DOI: https://doi.org/10.1007/s10517-021-05192-6

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