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Simple and Sensitive Multi-components Detection Using Synthetic Nitrogen-doped Carbon Dots Based on Soluble Starch

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Abstract

Although carbon dots (CDs) as fluorescent sensors have been widely exploited, multi-component detection using CDs without tedious surface modification is always a challenging task. Here, two kinds of nitrogen-doped CDs (NCD-m and NCD-o) based on soluble starch (SS) as carbon source were prepared through one-pot hydrothermal process using m-phenylenediamine and o-phenylenediamine as nitrogenous dopant respectively. Through fluorescence “on–off” mechanism of CDs, NCD-m and NCD-o could be used as a fluorescence sensor for detection of Fe 3+ and Ag + with LOD of 0.25 and 0.51 μM, respectively. Additionally, NCD-m could be used for indirect detection of ascorbic acid (AA) with LOD of 5.02 μM. Moreover, fluorescence intensity of NCD-m also exhibited the sensitivity to pH change from 2 to 13. More importantly, Both NCD-m and NCD-o had potential application for analysis of complicated real samples such as tap water, Vitamin C tablets and orange juice. Ultimately, the small size of NCD-m could contribute to reinforcing intracellular endocytosis, which allowed them to be used for bacteria imaging. Obviously, these easily obtainable nitrogen-doped CDs were able to be used for multi-components detection.

Graphical abstract

Strategy for synthesis of nitrogen-doped carbon dots (NCDs) and a schematic for fabrication of as-prepared NCDs for detection of Fe 3+, Ag + and ascorbic acid (AA).

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All data generated or analyzed during this study are included in this published article and its supplementary materials.

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Funding

This study was funded by the National Natural Science Foundation of China (No.81902168).

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Authors and Affiliations

  1. Medical College, China Three Gorges University, Yichang, 443002, China

    Yuanyuan Hu & Wenxuan Ji

  2. Third-Grade Pharmacological Laboratory On Traditional Chinese Medicine (Approved By State Administration of Traditional Chinese Medicine of China, SATCM), China Three Gorges University, Yichang, 443002, China

    Yuanyuan Hu

  3. Department of Medical Laboratory, Weifang Medical University, Weifang, 261053, China

    Jinjuan Qiao & Heng Li

  4. School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, China

    Yun Zhang

  5. The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China

    Jun Luo

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  1. Yuanyuan Hu
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Contributions

Yuanyuan Hu conceived and designed the study. Jun Luo conducted the literature search. Yuanyuan Hu and Wenxuan Ji performed the related experiments. Yuanyuan Hu, Wenxuan Ji, Jinjuan Qiao, Heng Li, Yun Zhang, and Jun Luo were involved in the analysis and interpretation of data. Yuanyuan Hu and Jun Luo drafted the manuscript. The study was supervised by Jinjuan Qiao, Heng Li and Yun Zhang. All authors read and approved the final manuscript.

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Correspondence to Yuanyuan Hu or Jun Luo.

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Hu, Y., Ji, W., Qiao, J. et al. Simple and Sensitive Multi-components Detection Using Synthetic Nitrogen-doped Carbon Dots Based on Soluble Starch. J Fluoresc 31, 1379–1392 (2021). https://doi.org/10.1007/s10895-021-02764-7

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