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The Putative Role of m6A-RNA Methylation in Memory Consolidation

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Abstract—Intermediate memory is one of the stages in the process of memory consolidation and completely disappears by the beginning of the appearance of long-term memory. This stage depends on translation but not transcription, and is also accompanied by the activation of protein synthesis. RNA modifications called epitranscriptome, especially N6-methyladenosine (m6A) methylation, may be involved in the regulation of this process. Numerous studies showed a general translation-stimulating effect of m6A and an increase in the amount of this modification in mRNA of animal neurons after training. Modulation of individual enzymes associated with m6A resulted in both impairment and enhancement of memory consolidation. In this review, a hypothetical model of their participation in memory consolidation is put forward on the basis of data on changes in the RNA of m6A methylome and the behavior of FTO demethylase in neurons of trained animals. In addition, other epigenetic and epitranscriptome mechanisms that potentially regulate this process are considered.

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Funding

This study was funded by the State Task Program for 2019–2021 (project no. АААА-А17-117092040002-6).

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  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul. Butlerova 5a, 117485, Moscow, Russia

    D. A. Novikov, A. P. Beletsky & P. M. Kolosov

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Novikov, D.A., Beletsky, A.P. & Kolosov, P.M. The Putative Role of m6A-RNA Methylation in Memory Consolidation. Neurochem. J. 15, 103–113 (2021). https://doi.org/10.1134/S1819712421020112

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