Skip to main content
Log in

Creating Tubular Structures from Tissue Spheroids via the Acoustic Radiation Force

  • Published:
Bulletin of the Russian Academy of Sciences: Physics Aims and scope

Abstract

A method is proposed of fabricating tubular constructs from tissue spheroids (conglomerates of cells up to 200 μm in size) in a nutrient fluid using the acoustic radiation force. The source of the acoustic field is a hollow piezoceramic cylinder with a resonant frequency of 800 kHz. Keeping the obtained structure at 37°C for 24 h fuses the spheroids into a solid tubular viable tissue construct.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Hesuani, Y.D., Pereira, F.D., Parfenov, V.A., et al., 3D Print. Addit. Manuf., 2016, vol. 3, no. 1, p. 64.

    Google Scholar 

  2. Parfenov, V.A., Koudan, E.V., Bulanova, E.A., et al., Biofabrication, 2018, vol. 10, no. 3, 034104.

    Article  ADS  Google Scholar 

  3. Krokhmal, A., Sapozhnikov, O., Koudan, E., et al., Proc. Meet. Acoust., 2019, vol. 38, no. 1, 020006.

    Article  Google Scholar 

  4. Krokhmal, A.A., Sapozhnikov, O.A., Tsysar, S.A., et al., Uch. Zap. Fiz. Fak. Mosk. Gos. Univ., 2020, no. 1, 2010902.

  5. Parfenov, V.A., Mironov, V.A., Koudan, E.V., et al., Sci. Rep., 2020, vol. 10, 4013.

    Article  ADS  Google Scholar 

  6. Parfenov, V.A., Khesuani, Y.D., Petrov, S.V., et al., Sci. Adv., 2020, vol. 6, no. 29, eaba4174.

  7. Parfenov, V.A., Koudan, E.V., Krokhmal, A.A., et al., Adv. Healthcare Mater., 2020, 2000721.

  8. Gryadunova, A.A., Bulanova, E.A., Kudan, E.V., et al., Klin. Eksp. Morfol., 2019, vol. 8, no. 2, p. 12.

    Google Scholar 

  9. Cathignol, D., Sapozhnikov, O.A., and Zhang, J., J. Acoust. Soc. Am., 1997, vol. 101, p. 1286.

    Article  ADS  Google Scholar 

  10. Tikhonov, A.N. and Samarskii, A.A., Uravneniya matematicheskoi fiziki (Equations of Mathematical Physics), Moscow: Nauka, 1966.

  11. Andreev, V.G., Demin, I.Y., Korolkov, Z.A., and Shanin, A.V., Bull. Russ. Acad. Sci.: Phys., 2016, vol. 80, no. 10, p. 1191.

    Article  Google Scholar 

  12. Gorkov, L.P., Sov. Phys. Dokl., 1962, vol. 6, p. 773.

    ADS  Google Scholar 

  13. Sapozhnikov, O.A. and Bailey, M.R., J. Acoust. Soc. Am., 2013, vol. 133, no. 2, p. 661.

    Article  ADS  Google Scholar 

Download references

Funding

This work was supported by the Russian Foundation for Basic Research, projects no. 20-32-90093, 20-02-00139, and 18-29-11076; and by the Basis Foundation for the Advancement of Theoretical Physics and Mathematics.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. A. Krokhmal.

Additional information

Translated by K. Gumerov

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Krokhmal, A.A., Sapozhnikov, O.A., Koudan, E.V. et al. Creating Tubular Structures from Tissue Spheroids via the Acoustic Radiation Force. Bull. Russ. Acad. Sci. Phys. 85, 681–685 (2021). https://doi.org/10.3103/S1062873821060137

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/S1062873821060137

Navigation