Medicine in focus
Why is PAK4 overexpressed in cancer?

https://doi.org/10.1016/j.biocel.2021.106041Get rights and content
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Abstract

Understanding why proteins are overexpressed in cancer is of great interest, as it holds the potential for improved cancer diagnosis and treatment. A noteworthy candidate, p21-activated kinase 4 (PAK4), is frequently overexpressed in cancer and a key player in multiple hallmarks of cancer. Here we review findings backing PAK4 overexpression in cancer and motivate PAK4 as a suitable target for the development of cancer therapy.

Keywords

p21-activated kinase
Protein overexpression
Cellular senescence
Cancer

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