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Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital

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Abstract

This study aimed to investigate the effects of a 4-year antibiotic stewardship program (ASP) in a tertiary hospital. We monitored data for 2015 (pre-intervention) and 2016–2019 (post-intervention) about antibiotic consumption (DDD/100 bed days), Clostridioides difficile infections (CDIs), resistance rates, length of stay (LOS), and annual antibiotic costs. Significant reductions were observed for total antibiotics/colistin/carbapenems/quinolones/tigecycline consumption and resistance rates of Pseudomonas aeruginosa, Klebsiella pneumoniae, and vancomycin-resistant enterococci. Considerable reductions occurred for LOS (4.18 [2015]/3.0 [2019] days), CDIs (1.47 [2015]/0.86 [2019] per 1000 patients), antibiotic cost/patient (39.45€ [2015]/23.69€ [2019]). The ASP was successful in reducing antibiotic consumption, antibiotic costs, length of hospital stay, and CDIs.

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All study data can be available upon request.

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Authors and Affiliations

  1. Department of Microbiology, National and Kapodistrian University of Athens, Athens, Greece

    Konstantina Chrysou, Athanasios Tsakris & Spyros Pournaras

  2. Department of Clinical Microbiology, Tzaneio General Hospital of Piraeus, Athens, Greece

    Olympia Zarkotou, Panagiota Papagiannakopoulou, Vasiliki Mamali & Katina Themeli-Digalaki

  3. Hospital Pharmacy, Tzaneio General Hospital of Piraeus, Athens, Greece

    Sofia Kalofolia

  4. 2nd Department of Medicine and Infectious Disease Unit, Tzaneio General Hospital of Piraeus, Athens, Greece

    Georgios Chrysos

  5. General Hospital of Athens “Laiko”, National and Kapodistrian University of Athens, Athens, Greece

    Nikolaos Sypsas

  6. Laboratory of Clinical Microbiology, ATTIKON University Hospital, National and Kapodistrian University of Athens, 1 Rimini Street, 12462, Chaidari, Athens, Greece

    Spyros Pournaras

Authors
  1. Konstantina Chrysou
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  2. Olympia Zarkotou
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  3. Sofia Kalofolia
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  4. Panagiota Papagiannakopoulou
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  5. Vasiliki Mamali
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  6. Georgios Chrysos
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  7. Katina Themeli-Digalaki
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  8. Nikolaos Sypsas
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  9. Athanasios Tsakris
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  10. Spyros Pournaras
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Correspondence to Spyros Pournaras.

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Chrysou, K., Zarkotou, O., Kalofolia, S. et al. Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital. Eur J Clin Microbiol Infect Dis 41, 127–132 (2022). https://doi.org/10.1007/s10096-021-04290-7

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  • DOI: https://doi.org/10.1007/s10096-021-04290-7

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