ReviewInfluential role of 7-Ketocholesterol in the progression of Alzheimer’s disease
Abbreviations
MPTP
1-Methyl-1, 2, 3, 6-tetrahydropyridine
7KCh
7-ketocholesterol
24S-OHC
24S-hydroxycholesterol
27-OHC
27-hydroxycholesterol
ACOX1
acyl-coA oxidase -1
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
αSyn
alpha synuclein
AD
Alzheimer’s disease
Aβ
amyloid beta
APP
amyloid precursor protein
ApoE
apolipoprotein E
ASK 1
apoptosis signal-regulating kinase 1
ABCA 1
ATP-binding cassette transporter A1
ABCG 1
ATP-binding cassette transporter G1
Abcd1
ATP binding cassette subfamily D 1
Abcd2
ATP binding cassette subfamily D 2
Bcl-2
B cell lymphoma -2
BAX
B cell lymphoma associated X
BACE 1
beta-site amyloid precursor protein cleaving enzyme
Bid
BH3 interacting- domain death agonist
BBB
blood brain barrier
BDNF
brain-derived neurotrophic factor
Ca2+
calcium
CMA
chaperone-mediated autophagy
CYP7A1
cholesterol 7 alpha-hydroxylase
CHOP
C/EBP homologous protein
Chr
chromosome
CoQ10
coenzyme Q10
CYPs
cytochrome p450
DRM
detergent resistant membrane
Drp1
dynamin-related protein 1
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinases
EALP
endosome-autophagosome-lysosome pathway
ESCRT
endosomal sorting complex required for transport
GSH
glutathione
eIF2α
eukaryotic translation initiator factor-2α
GRP78
glucose-related protein 78
GSK 3
glycogen synthase kinase -3
HO-1
heme oxygenase-1
HT-29
human colon cancer cell line
HUVEC-CS
human umbilical vein endothelial cells
H2O2
hydrogen peroxide
ICAM
intercellular adhesion molecule
IRE1
inositol-requiring enzyme-1
ILVs
intraluminal vesicles
JNK
c-Jun N-terminal kinase
iNOS
Inducible nitric oxide synthase
LDL
Low-density lipoprotein
LDLR
low-density lipoprotein receptor
LAMP2
lysosomal membrane-associated protein 2
LMP
lysosomal membrane permeabilization
MC-SF
macrophage colony-stimulating factor
MMP-9
matrix metalloproteinases
MAMs
mitochondria-associated membranes
mt DNA
mitochondrial DNA
Fis1
mitochondrial fission protein 1
Mfn1
mitofisin-1
Mfn2
mitofisin -2
MVBs
multivesicular bodies
Mfp2
multifunctional protein- 2
NOX-4
NADPH oxidase 4
NGF
Nerve growth factor
NFT
neurofibrillary tangle
NADH
nicotinamide adenine dinucleotide
NADPH
nicotinamide adenine dinucleotide phosphate
NFE2L2
nuclear factor, erythroid 2- like 2
NF-κB
nuclear factor kappa B
Opa1
optic atrophy protein
PERK
pancreatic ER kinase
PI3K
phosphatidylinositol 3-kinase
p53
phosphoprotein 53
PARP-1
poly (ADP-ribose) polymerase
PGE2
prostaglandin E2
PSEN1
presenilin 1
PSEN2
presenilin 2
P38
p38 mitogen-activated protein kinase
ROS
reactive oxygen species
Sig-1R
sigma-1 receptor
Src
steroid activated protein
TFEB
transcription factor EB
TNF-R2
TNF- receptor 2
UPR
unfolded protein response
VLCFAs
very long chain fatty acids
VWF
von Willebrand factor
XBP1
X-box binding protein 1
X-ALD
X-linked adrenoleukodystrophy
Keywords
Neurodegenerative diseases
Alzheimer’s disease
7-Ketocholesterol
Neurons
Oxidative stress
Amyloid-β peptide
Mitochondria
Lysosome
Peroxisome
Endoplasmic reticulum
Microglial activation
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