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Isolation and Characterization of Hepatoprotective Anthraquinone Derivatives from Cucumis bisexualis

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Chemistry of Natural Compounds Aims and scope

A new anthraquinone, named 1,3-dihydroxy-2-methylene-(1′-isopentyloxy)-6-methoxymethyl-8-(6′′,7′′,8′′- trihydroxyphenylketonyl)-9,10-anthraquinone (1), and nine known anthraquinone derivatives (2–10), were isolated from Cucumis bisexualis for the first time. Compounds 1–10 were evaluated for their hepatoprotective activity in human L-O2 cells compared with the positive control bifendatatum. Among them, compounds 1, 3, and 8 exhibited moderate hepatoprotective activity in the proliferation of L-O2 cells.

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Acknowledgment

This study was supported by the Natural Science Foundation of Jiangxi Province (20202BAB206078).

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Authors and Affiliations

  1. Key Laboratory of Modern Preparation of TCM of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, P. R. China

    Qinge Ma & Rongrui Wei

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  1. Qinge Ma
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  2. Rongrui Wei
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Correspondence to Rongrui Wei.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2021, pp. 538–540.

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Ma, Q., Wei, R. Isolation and Characterization of Hepatoprotective Anthraquinone Derivatives from Cucumis bisexualis. Chem Nat Compd 57, 627–630 (2021). https://doi.org/10.1007/s10600-021-03437-4

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  • DOI: https://doi.org/10.1007/s10600-021-03437-4

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