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The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation

The Journal of Antibiotics volume 74, pages 580–592 (2021)Cite this article

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Abstract

Amikacin (AMK) is one of the most effective aminoglycoside antibiotics. However, nephrotoxicity is a major deleterious and dose-limiting side effect associated with its clinical use especially in high dose AMK-treated patients. The present study assessed the ability of taurine (TAU) to alleviate or prevent AMK-induced nephrotoxicity if co-administrated with AMK focusing on inflammation, apoptosis, and fibrosis. Male Sprague Dawley rats were assigned to six equal groups. Group 1: rats received saline (normal control), group 2: normal rats received 50 mg kg−1 TAU intraperitoneally (i.p.). Groups 3 and 4: received AMK (25 or 50 mg kg−1; i.p.). Groups 5 and 6: received TAU (50 mg kg−1; i.p.) concurrently with AMK (25 or 50 mg kg−1; i.p.) for 3 weeks. AMK-induced nephrotoxicity is evidenced by elevated levels of serum creatinine (CRE), blood urea nitrogen (BUN), and uric acid (UA). Histopathological investigations provoked damaging changes in the renal tissues. Heat shock proteins (HSP)25 and Toll-like receptor-4 (TLR-4) elevated levels were involved in the induction of inflammatory reactions and focal fibrosis. The improved activation of TLR-4 may stimulate monocytes to upgrade Interleukin (IL)-18 production rather than IL-10. TAU proved therapeutic effectiveness against AMK-induced renal toxicity through downregulation of HSP25, TLR-4, caspase-3, and IL-18 with up-regulation of IL-10 levels.

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  1. Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt

    Neveen Madbouly, Ayman Azmy & Azza El-Amir

  2. Pharmacology Department, National Research Centre, Cairo, Egypt

    Abeer Salama

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Madbouly, N., Azmy, A., Salama, A. et al. The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation. J Antibiot 74, 580–592 (2021). https://doi.org/10.1038/s41429-021-00441-2

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