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Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Several neurological diseases are accompanied by rhythmic oscillatory dysfunctions in various frequency ranges and disturbed cross-frequency relationships on regional, interregional, and whole brain levels. Knowledge of these disease-specific oscillopathies is important mainly in the context of deep brain stimulation (DBS) therapy. Electrophysiological biomarkers have been used as input signals for adaptive DBS (aDBS) as well as preoperative outcome predictors. As movement disorders, particularly Parkinson’s disease (PD), are among the most frequent DBS indications, the current research of DBS is the most advanced in the movement disorders field. We reviewed the literature published mainly between 2010 and 2020 to identify the most important findings concerning the current evolution of electrophysiological biomarkers in DBS and to address future challenges for prospective research.

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Acknowledgements

Thanks to Anne Johnson for English language assistance.

Funding

This work has been financially supported by grants: Czech science foundation GAČR 21-25953S and Czech health research council AZV NU21-04–00445.

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Authors and Affiliations

  1. Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Brno, Czech Republic

    Martina Bočková & Ivan Rektor

  2. Movement Disorders Center, First Department of Neurology, Masaryk University School of Medicine, St. Anne’s Hospital, Pekařská 53, 656 91, Brno, Czech Republic

    Martina Bočková & Ivan Rektor

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  1. Martina Bočková
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  2. Ivan Rektor
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Correspondence to Ivan Rektor.

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Bočková, M., Rektor, I. Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges. J Neural Transm 128, 1169–1175 (2021). https://doi.org/10.1007/s00702-021-02381-5

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  • DOI: https://doi.org/10.1007/s00702-021-02381-5

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