Abstract
HSPB5 (heat shock protein B5), also known as αB-crystallin, is one of the most widespread and populous of the ten human small heat shock proteins (sHsps). Over the past decades, extensive research has been conducted on HSPB5. However, few studies have statistically analyzed these publications. Herein, we conducted a bibliometric analysis to track the global research trend and current development status of HSPB5 research from the Web of Science Core Collection (WoSCC) database between 1985 and 2020. Our results demonstrate that 1220 original articles cited 54,778 times in 391 scholarly journals were published. Visualization analyses reveal that the Journal of Biological Chemistry was the most influential journal with 85 articles. The USA dominated this field with 520 publications (42.62%), followed by Japan with 149 publications (12.21%), and Kato contributed the largest number of publications. Most related publications were published in journals focusing on biochemistry molecular biology, cell biology, neurosciences neurology, and ophthalmology. In addition, keyword co-occurrence analyses identify three predominant research topics: expression of HSPB5, chaperone studies for HSPB5, and pathological studies of HSPB5. This study provides valuable guidance for researchers and leads to collaborative opportunities between diverse research interests to be integrated for HSPB5 research.
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Abbreviations
- ACD:
-
α-crystallin domain
- AD:
-
Alzheimer’s disease
- Aβ:
-
amyloid-beta
- IF:
-
impact factor
- sHsps:
-
small heat shock proteins
- ThT:
-
thioflavin T
- WoSCC:
-
Web of Science Core Collection
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We thank our reviewers for excellent comments and suggestions regarding the content and style of the manuscript.
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This work has been supported by the financial support from the Natural Science Foundation of Shanghai (Grant No. 19ZR1453100).
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Zhengdong Xu, Jiaqian Wan, and Jiaxing Tang conducted the literature search and screened and extracted data for the bibliometric analysis. Zhengdong Xu had primary responsibility in writing this article. Yehong Gong made the contribution in the process of discussion and editing. Qingwen Zhang critically revised the draft manuscript. All authors read and approved the final manuscript.
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Xu, Z., Gong, Y., Wan, J. et al. Trends in HSPB5 research: a 36-year bibliometric analysis. Cell Stress and Chaperones 26, 799–810 (2021). https://doi.org/10.1007/s12192-021-01220-6
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DOI: https://doi.org/10.1007/s12192-021-01220-6