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Near-infrared emission carrier, Er3+-doped ZnAl-LDH, for delivery and release of ibuprofen in vitro

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
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Abstract

A drug delivery system with near-infrared emissions response to drug delivery and release is essential as marking or targeting drug delivery system. For this reason, the Er3+-doped ZnAl-LDH with near-infrared emissions was used for the first time for controlled release of the ibuprofen (IBU) that is a non-steroidal antiinflammatory drug. The drug release was controlled in simulated intestinal medium (pH 7.4 phosphate buffer solutions at 37 °C). The release kinetics showed an initial burst release followed by a slow release of IBU. The most important thing is that the intercalation of IBU into the Er3+-doped ZnAl-LDH greatly reduced the near-infrared emissions of the Er3+-doped ZnAl-LDH, whereas the near-infrared emissions were recovered after the IBU was released from the Er3+-doped ZnAl-LDH delivery system. This change of near-infrared emissions would provide a useful technique for in situ monitoring of the delivery and release of IBU. The Er3+-doped ZnAl-LDH with near-infrared emissions is inexpensive, biocompatible, nontoxic, and little damage to biological tissue, which would be potential application as drug delivery system with marking or targeting performance.

ZnAl-Er-LDH drug delivery system exhibits great changes in the intensity of infrared emissions before drug delivery, during drug delivery, and after drug release. This change of infrared emissions would provide a useful technique for in situ monitoring of the delivery and release of ibuprofen at target sites.

Highlights

  • An infrared emission carrier for the delivery system of ibuprofen based on Er3+-doped ZnAl-LDH was reported for the first time.

  • The release kinetics of ibuprofen from the Er3+-doped ZnAl-LDH delivery system has been investigated.

  • The near infrared emissions of Er3+-doped LDH drug delivery system obviously response to the delivery and release of ibuprofen.

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Acknowledgements

This work is supported financially by the National Natural Science Foundation of China (51864033, 21978127) and the National Key Research Development Program of China (2019YFC0605000).

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Authors and Affiliations

  1. College of Chemistry, Nanchang University, Nanchang, 330031, China

    Chao Li, Hongbo Zhou, Yajiao Zhang, Yongxiu Li & Yufeng Chen

  2. Mount Holyoke College, South Hadley, MA, 01075, USA

    Siyu Yin

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  1. Chao Li
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  2. Siyu Yin
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Li, C., Yin, S., Zhou, H. et al. Near-infrared emission carrier, Er3+-doped ZnAl-LDH, for delivery and release of ibuprofen in vitro. J Sol-Gel Sci Technol 99, 430–443 (2021). https://doi.org/10.1007/s10971-021-05575-1

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