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PARKINSON DISEASE

Parkinson disease and air pollution: does what we breathe matter?

Nature Reviews Neurology volume 17, pages 467–468 (2021)Cite this article

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Results of a new study have identified an association between risk of incident Parkinson disease and exposure to NO2, which is released into the atmosphere as a result of burning fuels. Parkinson disease has a long prodromal phase, so these findings suggest an opportunity to apply early prevention strategies.

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References

  1. Jo, S. et al. Association of NO2 and other air pollution exposures with the risk of Parkinson disease. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2021.1335 (2021).

    Article  PubMed  Google Scholar 

  2. Marras, C. et al. Prevalence of Parkinson’s disease across North America. NPJ Parkinsons Dis. 4, 21 (2018).

    Article  CAS  Google Scholar 

  3. Fleury, V. et al. Geospatial analysis of individual-based Parkinson’s disease data supports a link with air pollution: A case-control study. Parkinsonism Relat. Disord. 83, 41–48 (2021).

    Article  Google Scholar 

  4. Ritz, B. et al. Traffic-related air pollution and parkinson’s disease in Denmark: a case-control study. Environ. Health Perspect. 124, 351–356 (2016).

    Article  CAS  Google Scholar 

  5. Nunez, Y. et al. Fine particle exposure and clinical aggravation in neurodegenerative diseases in New York State. Environ. Health Perspect. 129, 27003 (2021).

    Article  Google Scholar 

  6. Palacios, N. et al. Air pollution and risk of Parkinson’s disease in a large prospective study of men. Environ. Health Perspect. 125, 087011 (2017).

    Article  Google Scholar 

  7. Heinzel, S. et al. Update of the MDS research criteria for prodromal Parkinson’s disease. Mov. Disord. 34, 1464–1470 (2019).

    Article  Google Scholar 

  8. Calderón-Garcidueñas, L. et al. Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal. Environ. Res. 191, 110139 (2020).

    Article  Google Scholar 

  9. Calderón-Garcidueñas, L. et al. Reduced repressive epigenetic marks, increased DNA damage and Alzheimer’s disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution. Environ Res. 183, 109226 (2020).

    Article  Google Scholar 

  10. Karanth, S. et al. Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults. JAMA Neurol. 77, 1299–1307 (2020).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Biomedical Sciences, The University of Montana, Missoula, MT, USA

    Lilian Calderón-Garcidueñas

  2. Universidad del Valle de México, Mexico City, México

    Lilian Calderón-Garcidueñas

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  1. Lilian Calderón-Garcidueñas
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Correspondence to Lilian Calderón-Garcidueñas.

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The author declares no competing interests.

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Calderón-Garcidueñas, L. Parkinson disease and air pollution: does what we breathe matter?. Nat Rev Neurol 17, 467–468 (2021). https://doi.org/10.1038/s41582-021-00531-7

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