Prediction of new onset of diabetes mellitus during a 10-year period by using a combination of levels of alanine aminotransferase and γ-glutamyl transferase

Daisuke Miyamori; Marenao Tanaka; Masato Furuhashi; Hirofumi Ohnishi; Masayuki Koyama; Arata Osanami; Yukimura Higashiura; Keita Numata; Takashi Hisasue; Nagisa Hanawa; Norihito Moniwa; Tetsuji Miura

doi:10.1507/endocrj.EJ20-0823

ORIGINAL

Prediction of new onset of diabetes mellitus during a 10-year period by using a combination of levels of alanine aminotransferase and γ-glutamyl transferase

Daisuke Miyamori, Marenao Tanaka, Masato Furuhashi, Hirofumi Ohnishi, Masayuki Koyama, Arata Osanami, Yukimura Higashiura, Keita Numata, Takashi Hisasue, Nagisa Hanawa, Norihito Moniwa, Tetsuji Miura

Author information

Daisuke Miyamori
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Marenao Tanaka
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Tanaka Medical Clinic, Yoichi 046-0021, Japan
Masato Furuhashi
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Hirofumi Ohnishi
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Department of Public Health, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Masayuki Koyama
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Department of Public Health, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Arata Osanami
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Yukimura Higashiura
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Keita Numata
Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo 064-0820, Japan
Takashi Hisasue
Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo 064-0820, Japan
Nagisa Hanawa
Department of Health Checkup and Promotion, Keijinkai Maruyama Clinic, Sapporo 064-0820, Japan
Norihito Moniwa
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Tetsuji Miura
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan

Keywords: Diabetes mellitus, Alanine aminotransferase, γ-glutamyltransferase, Liver enzyme

JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary material

2021 Volume 68 Issue 12 Pages 1391-1402

DOI https://doi.org/10.1507/endocrj.EJ20-0823

Browse “Advance online publication” version

Details

Abstract

Levels of alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) have been reported to be associated with increased risk of diabetes mellitus (DM). However, whether a combination of levels of ALT and GGT predicts new onset of DM better than does ALT or GGT alone in both males and females has not fully been addressed. We investigated the relationship between the combination of ALT and GGT and DM development during a 10-year follow-up period in 13,919 subjects (male/female: 8,983/4,936; age 48 ± 10 years) who received health examinations. During the 10-year period, 617 males (6.9%) and 153 females (3.1%) had new onset of DM. Multivariable Cox proportional hazard models with a restricted cubic spline showed that hazard ratios (HRs) of DM development increased with higher levels of ALT and GGT at baseline in both sexes after adjustment of confounding factors. When divided into 4 subgroups of high (H-) and low (L-) levels of ALT (male/female: 27/21 U/L) and GGT (male/female: 43/23 U/L) using cutoff values shown by receiver operating characteristic curve analyses, the adjusted HR in the H-ALT/H-GGT group was significantly higher than HR in the L-ALT/L-GGT group as the reference in males (HR [95% confidence interval]: 1.73[1.36–2.20], p < 0.001) but was not significantly higher in females (1.50 [0.97–2.33], p = 0.065). The addition of the combination of H-ALT/H-GGT to traditional risk factors with and without H-ALT or H-GGT alone significantly improved the discriminatory capability for predicting development of DM. In conclusion, the combination of H-ALT/H-GGT efficiently predicts development of DM in male individuals but not significantly in female individuals.

Corresponding author

Register with J-STAGE for free!