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Kinetic Modeling of Mitochondrial-Reticular Network Dynamics

  • CELL BIOPHYSICS
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Abstract

This study involves the mitochondrial-reticular network, which is functionally integrated into the processes that provide energy to all systems of an organism as an open, dynamic, self-regulatory organization involved in the energy homeostasis of the cell under the control of AMP-activated protein kinase as the main energy indicator. The mitochondrial-reticular network is regulated by at least three multidirectional energy vectors, that is, mitochondrial fission and fusion, and mitochondrial apoptosis mechanisms. A kinetic mathematical model of the mitochondrial-reticular network function is proposed. The search for effective strategies for the functioning of mitochondrial-reticular network is resolved into constrained optimization through the use of the Lagrange multiplier.

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Authors and Affiliations

  1. St. Petersburg State University, 199034, St. Petersburg, Russia

    G. V. Kudryavtseva, Yu. A. Malenkov, V. V. Shishkin, V. I. Shishkin & A. A. Kartunen

Authors
  1. G. V. Kudryavtseva
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  2. Yu. A. Malenkov
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  3. V. V. Shishkin
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  4. V. I. Shishkin
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  5. A. A. Kartunen
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Corresponding author

Correspondence to G. V. Kudryavtseva.

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CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

COMPLIANCE WITH ETHICAL STANDARDS

The study was performed without the use of animals or people as subjects.

Additional information

Translated by P. Kuchina

Abbreviations: MRN, mitochondrial-reticular network; ESC, energy supply chains (respiratory mitochondrial chain).

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Kudryavtseva, G.V., Malenkov, Y.A., Shishkin, V.V. et al. Kinetic Modeling of Mitochondrial-Reticular Network Dynamics. BIOPHYSICS 66, 240–247 (2021). https://doi.org/10.1134/S0006350921020135

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  • DOI: https://doi.org/10.1134/S0006350921020135

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