Abstract
This study integrates developmental and life-course criminology with advances in socio-genomics to investigate the complex relationships among criminal justice (CJ) involvement (e.g., arrest, conviction, and incarceration), educational attainment, and genetic inheritance. Using data from the National Longitudinal Study of Adolescent to Adult Health, we conduct an analysis based on a whole-genome polygenic score for educational attainment. We find that participants with lower polygenic scores for educational attainment were significantly more likely to report CJ involvement during adolescence. We then show that the association between the education polygenic score and adolescent CJ involvement risk may be attributed to gene-environment correlation mechanisms that operate via both individual factors (e.g., psychopathic personality traits and delinquency) and social factors (e.g., family characteristics and school experiences). Finally, we find evidence that adolescent CJ involvement mediates the association between the education polygenic score and male participants’ actual educational attainment. Results also indicate that the influence of CJ involvement on education was partially confounded by genetic factors. Findings in this paper not only enrich existing criminological theories on the causes and consequences of CJ involvement in the life-course process but also help to improve causal inference in the study of the impact of CJ involvement on later-in-life outcomes.
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In GWA studies, genomes from a large sample of individuals are scanned to search for genetic variants that can be used to predict the outcome. The GWA analysis typically involves two steps. First, each genetic variant is used to predict the phenotype and the corresponding p value is recorded. Because the prediction involves a large number of genetic variables, it is likely that some small p values are due to chance. To address the multiple testing issue, a conservative p value threshold is set as 5 × 10−8 or smaller. Second, even extremely smaller p values do not completely rule out all possible false-positives, thus replication using independent data is required to establish validity of a GWA study.
Over 93% of Add Health participants completed high school or earned a high school equivalency degree.
Each genotype typically has only two alleles. There are three possible combinations of two alleles in a population (e.g., AA, CC, and AC). Effect allele is the one positively associated with the outcome.
Population stratification refers to the presence of a systematic difference in the genetic distribution between subpopulations. Population stratification is a primary consideration in genome-wide association studies. Failure to control for it may lead to false results. Principal component analysis has been developed as a standard approach to address population stratification in regression analysis.
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Funding
This research uses data from Add Health, a program project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill, and funded by grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 23 other federal agencies and foundations. This research uses Add Health GWAS data funded by NICHD grants R01 HD073342 and R01 HD060726. Information on how to obtain the Add Health data files is available on the Add Health website (http://www.cpc.unc.edu/addhealth). This research benefits from GWAS results and polygenic scores made publicly available by the Social Science Genetic Association Consortium (SSGAC).
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Liu, H., Motz, R.T., Tanksley, P.T. et al. Adolescent Criminal Justice Involvement, Educational Attainment, and Genetic Inheritance: Testing an Integrative Model Using the Add Health Data. J Dev Life Course Criminology 7, 195–228 (2021). https://doi.org/10.1007/s40865-021-00166-8
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DOI: https://doi.org/10.1007/s40865-021-00166-8