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Heat shock proteins: a history of study in Russia

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Cell Stress and Chaperones Aims and scope

Abstract

This review describes a brief history of the discovery and studies in Russia and associated countries of the main stress protein (Hsp70) that plays important roles both in the normal function of the cell and body as well as under various stressful stimuli. Research on this protein at the Institute of Molecular Biology (Moscow) began with the elucidation of its adaptive functions at the cellular level and at the level of the whole organism. These studies examined the function of Hsp70 under normal and extreme conditions using a wide range of model and non-model animal species, from Leishmania and Drosophila to camels and humans. These analyses made it possible to elucidate the primary regulations in the evolution and function of heat shock (HS) genes in the studied organisms. Next, we studied the structure and characteristic features of heat shock genes and proteins in species with contrasting habitat temperatures. The systems of Hsp70 expression and isolation we developed using various research objects allowed us to proceed to study the protective properties of human recombinant Hsp70 in normal-aging animal models as well as animal models experiencing sepsis, Alzheimer’s disease, and stroke. The results obtained open the prospects of using recombinant Hsp70 for the treatment of various neuropathologies in humans. This review describes the logic and history of investigation of Hsp70 performed by one group of scientists from Engelhardt Institute of Molecular Biology, Russian Academy of Sciences. It was not the goal of this paper to give a comprehensive general picture of other similar studies carried out in Russia during this period.

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Acknowledgements

Dozens of people from various institutes and universities in Russia and other countries participated in this long-term work to varying degrees. I would especially like to mention the role of the late Khayet Ulmasov, who conducted the primary field research in Turkmenistan, as well as my long-term collaborators Olga Zatsepina and David Garbuz, who participated in the study of Hsps during the main stages. I would also like to thank Natalia Bobkova, together with whom all the experiments on ageing and the study of AD models were performed, as well as Maxim Vinokurov and Marina Yurinskaya, who performed all the work with cell cultures. At many stages of the work, we discussed our results with Boris Margulis and Irina Guzhova, who are our co-authors on a number of articles. The author expresses his deep gratitude to Dr. Lawrence Hightower and Dr. Robert Tanguay for reading the MS and many useful suggestions and corrections.

Funding

This work was supported by Russian Science Foundation Grant 17-74-30030.

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  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    Mikhail Borisovich Evgen’ev

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  1. Mikhail Borisovich Evgen’ev
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Correspondence to Mikhail Borisovich Evgen’ev.

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Evgen’ev, M.B. Heat shock proteins: a history of study in Russia. Cell Stress and Chaperones 26, 617–627 (2021). https://doi.org/10.1007/s12192-021-01219-z

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