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Potential Therapeutic Effects of Melatonin Mediate via miRNAs in Cancer

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Abstract

miRNAs are evolutionarily conserved non-coding ribonucleic acids with a length of between 19 and 25 nucleotides. Because of their ability to regulate gene expression, miRNAs have an important function in the controlling of various biological processes, such as cell cycle, differentiation, proliferation, and apoptosis. Owing to the long-standing regulative potential of miRNAs in tumor-suppressive pathways, scholars have recently paid closer attention to the expression profile of miRNAs in various types of cancer. Melatonin, an indolic compound secreted from pineal gland and some peripheral tissues, has been considered as an effective anti-tumor hormone in a wide spectrum of cancers. Furthermore, it induces apoptosis, inhibits tumor metastasis and invasion, and also angiogenesis. A growing body of evidence indicates the effects of melatonin on miRNAs expression in broad spectrum of diseases, including cancer. Due to the long-term effects of the regulation of miRNAs expression, melatonin could be a promising therapeutic factor in the treatment of cancers via the regulation of miRNAs. Therefore, in this review, we will discuss the effects of melatonin on miRNAs expression in various types of cancers.

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Funding

This work financially supported by the Stem Cell and Regenerative Medicine Institute (SCARM) and Research Vice-Chancellor of Tabriz University of Medical Sciences (Ph.D. Thesis No. 59577).

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Author notes

  1. Pirouz Pourmohammad, Nazila Fathi Maroufi and Mohsen Rashidi have contributed equally to this article.

Authors and Affiliations

  1. Department of Clinical Biochemistry, School of Medicine, Ardabil University of Medical Science, Ardabil, Islamic Republic of Iran

    Pirouz Pourmohammad

  2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Nazila Fathi Maroufi & Yousef Faridvand

  3. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Nazila Fathi Maroufi, Hamid Reza Nejabati & Mohammad Nouri

  4. Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Mohsen Rashidi

  5. Researchers Club of Tums Preclinical Core Facility (TPCF), Tehran University of Medical Science (TUMS), Tehran, Iran

    Vahid Vahedian

  6. Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University (IAU), Sari, Iran

    Vahid Vahedian

  7. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Farhad Pouremamali

  8. Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran

    Mahsa Ghaffari-novin

  9. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Alireza Isazadeh & Saba Hajazimian

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  1. Pirouz Pourmohammad
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  2. Nazila Fathi Maroufi
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  10. Hamid Reza Nejabati
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  11. Mohammad Nouri
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Contributions

PP & NFM and MR Conceptualization, Writing—review & editing. VV: Writing -original draft. FP: Writing—review: YF & MG: editing. AI: Writing. SH Writing. MN Supervision. HN Supervision.

Corresponding authors

Correspondence to Hamid Reza Nejabati or Mohammad Nouri.

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Pourmohammad, P., Maroufi, N.F., Rashidi, M. et al. Potential Therapeutic Effects of Melatonin Mediate via miRNAs in Cancer. Biochem Genet 60, 1–23 (2022). https://doi.org/10.1007/s10528-021-10104-4

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