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Evaluation of the Gastroprotective Effect of the Flavonoid Complex from Lychnis chalcedonica L. on the Models of Experimental Ulcerogenesis

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Using rat and mouse models of neurogenic, ethanol-induced, and indometacin-induced damage to the gastric mucosa we demonstrated that course preventive treatment with flavonoid complex from aerial parts of Lychnis chalcedonica L. increased the resistance of gastric mucosa to ulcerogenic factors of different etiology. The gastroprotective effect of the phytocomplex in a dose range of 16-1600 μg/kg was comparable with that of the reference drug plantaglucide and was superior to that of the reference drugs eleutherococcus extract and methyluracil in the therapeutic doses. The antiulcerogenic activity of Lychnis chalcedonica flavonoid complex considerably exceeded activity of Lychnis chalcedonica L. extract demonstrated in our previous experiments.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    S. G. Krylova, O. G. Afanas’eva, Yu. V. Nesterova, O. Yu. Rybalkina, T. N. Povet’eva, E. P. Zueva, G. N. Zyuzkov & N. I. Suslov

  2. National Research Tomsk State University, Tomsk, Russia

    L. N. Zibareva

Authors
  1. S. G. Krylova
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  2. O. G. Afanas’eva
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  3. L. N. Zibareva
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  4. Yu. V. Nesterova
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  5. O. Yu. Rybalkina
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  6. T. N. Povet’eva
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  7. E. P. Zueva
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  8. G. N. Zyuzkov
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  9. N. I. Suslov
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Corresponding author

Correspondence to S. G. Krylova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 2, pp. 175-181, February, 2021

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Krylova, S.G., Afanas’eva, O.G., Zibareva, L.N. et al. Evaluation of the Gastroprotective Effect of the Flavonoid Complex from Lychnis chalcedonica L. on the Models of Experimental Ulcerogenesis. Bull Exp Biol Med 171, 212–217 (2021). https://doi.org/10.1007/s10517-021-05197-1

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  • DOI: https://doi.org/10.1007/s10517-021-05197-1

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