Abstract
Based on experimental data, we introduce and analyze a system of reaction-diffusion equations for the regeneration of planarian flatworms. We model dynamics of head and tail cells expressing positional control genes that translate into localized signals which in turn guide stem cell differentiation. Tissue orientation and positional information are encoded in a long range wnt-related signaling gradient. Our system correctly reproduces typical cut and graft experiments, and improves on previous models by preserving polarity in regeneration over orders of magnitude in body size during growth phases. Key to polarity preservation in our model flatworm is the sensitivity of cell differentiation to gradients of wnt-related signals relative to the tissue surface. This process is particularly relevant in small tissue layers close to cuts during their healing, and modeled in a robust fashion through dynamic boundary conditions.
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28 March 2022
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Acknowledgements
CT was supported by a fellowship of the Graduate School of the Cells-in-Motion Cluster of Excellence EXC 1003–CiM, University of Münster (WWU). ASc was partially supported through NSF grants DMS–1311740 and DMS–1907391, a Research Award from the Alexander-von-Humboldt Foundation, and a WWU Fellowship. ASc and ASt were supported by the DFG (German Research Foundation) under Germany’s Excellence Strategy EXC 2044-390685587, Mathematics Münster: Dynamics–Geometry–Structure. CT and ASt gratefully acknowledge numerous valuable discussions about the biology of planarians with Kerstin Bartscherer.
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Scheel, A., Stevens, A. & Tenbrock, C. Signaling gradients in surface dynamics as basis for planarian regeneration. J. Math. Biol. 83, 6 (2021). https://doi.org/10.1007/s00285-021-01627-w
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DOI: https://doi.org/10.1007/s00285-021-01627-w