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Electrocatalytic cascade approach to the synthesis of dihydro-2'H,3H-spiro[1-benzofuran-2,5'-pyrimidines]

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Chemistry of Heterocyclic Compounds Aims and scope

Electrocatalytic cascade assembly of benzylidenebarbiturates and cyclohexane-1,3-diones in methanol in the presence of sodium bromide as mediator in an undivided cell results in the formation of dihydro-2'H,3H-spiro[1-benzofuran-2,5'-pyrimidines] in 72–85% yields. This electrochemical process occurs under mild conditions, and the isolation procedure after the reaction is simple. The structures of the final compounds were confirmed by 1H–13C HMBC spectroscopy.

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The reported study was funded by the Russian Foundation for Basic Research (project No. 19-29-08013).

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia

    Fedor V. Ryzhkov, Michail N. Elinson, Yuliya E. Ryzhkova, Anatoly N. Vereshchagin, Artem N. Fakhrutdinov & Mikhail P. Egorov

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  1. Fedor V. Ryzhkov
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  2. Michail N. Elinson
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  3. Yuliya E. Ryzhkova
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  4. Anatoly N. Vereshchagin
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Correspondence to Fedor V. Ryzhkov.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(6), 672–678

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Ryzhkov, F.V., Elinson, M.N., Ryzhkova, Y.E. et al. Electrocatalytic cascade approach to the synthesis of dihydro-2'H,3H-spiro[1-benzofuran-2,5'-pyrimidines]. Chem Heterocycl Comp 57, 672–678 (2021). https://doi.org/10.1007/s10593-021-02966-8

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