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The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders

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A Correction to this article was published on 15 May 2021

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Abstract

Neurodevelopmental disorders are defined as a set of abnormal brain developmental conditions marked by the early childhood onset of cognitive, behavioral, and functional deficits leading to memory and learning problems, emotional instability, and impulsivity. Autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette syndrome, fragile X syndrome, and Down’s syndrome are a few known examples of neurodevelopmental disorders. Although they are relatively common in both developed and developing countries, very little is currently known about their underlying molecular mechanisms. Both genetic and environmental factors are known to increase the risk of neurodevelopmental disorders. Current diagnostic and screening tests for neurodevelopmental disorders are not reliable; hence, individuals with neurodevelopmental disorders are often diagnosed in the later stages. This negatively affects their prognosis and quality of life, prompting the need for a better diagnostic biomarker. Recent studies on microRNAs and their altered regulation in diseases have shed some light on the possible role they could play in the development of the central nervous system. This review attempts to elucidate our current understanding of the role that microRNAs play in neurodevelopmental disorders with the hope of utilizing them as potential biomarkers in the future.

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Funding

This review work was funded by the Fundamental Research Grant Scheme (FRGS) 203/PPSP/6171233, sponsored by Ministry of Higher Education, Malaysia.

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  1. Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

    Iman Imtiyaz Ahmed Juvale & Ahmad Tarmizi Che Has

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  1. Iman Imtiyaz Ahmed Juvale
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Iman Imtiyaz Ahmed Juvale: Designing and drafting the manuscript. Ahmad Tarmizi Che Has: Revising the manuscript critically and approving the manuscript to be published.

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Correspondence to Ahmad Tarmizi Che Has.

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The original online version of this article was revised: The bibliographic entries of “Chandley et al. 2015; Ciaccio et al. 2017; Curatolo et al. 2014; Frye et al. 2017; Green et al. 2019; Hamed et al. 2015; Huntley et al. 2012; Mor et al. 2015; Nakata et al. 2019; Novotny et al. 2018; Ornoy and Spivak 2019; and Pagliaroli et al. 2020” were incomplete. Full information regarding the corrections made can be found in the erratum/correction for this article.

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Juvale, I.I.A., Che Has, A.T. The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders. J Mol Neurosci 71, 1338–1355 (2021). https://doi.org/10.1007/s12031-021-01825-7

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