Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1867, Issue 12, 1 December 2021, 166204
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis
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Abbreviations
ATII
alveolar type II
BLM
bleomycin
DFO
deferoxamine
ATI
alveolar type I
ROS
reactive oxygen species
DMT1
divalent metal transporter 1
GF-AAS
Graphite furnace atomic absorption spectrometry
TfR1
Transferrin receptor protein 1
FPN
ferroportin-1
SP-C
surfactant protein C
α-SMA
α-smooth muscle actin
GPX4
glutathione peroxidase 4
ACSL4
Acyl—CoA synthetase long-chain familymember 4
FSP1
Ferroptosis suppressor protein 1
IRP1
iron-binding proteins and mRNA-regulatory proteins 1
IRP2
iron-binding proteins and mRNA-regulatory proteins 2
ΔΨm/MMP
mitochondrial membrane potential
ECM
extracellular matrix
IHC
Immunohistochemistry
Fer-1
Ferrostatin-1
PUFA
polyunsaturated fatty acids
BH
Bleomycin hydrolase
NCOA4
Nuclear receptor coactivator 4
PHD1
prolyl hydroxylase 1
LOX
lipoxygenase
HSPB1
heat shock protein β-1
CISD1
CDGSH iron sulfur domain 1
PRDX6
peroxide reduction enzyme-6
IRP-IRE
Iron regulatory protein (IRP)-iron responsive element (IRE)
Keywords
Pulmonary fibrosis
Ferroptosis
Alveolar type II cells
Iron deposition
Deferoxamine
Cited by (0)
- 1
The first authors contributed to this work.
- 2
Ziqiang Luo and Chen Li contributed equally to this work.
© 2021 Elsevier B.V.