Abstract
The aquaculture industry’s rapid growth to meet commercial demand can trigger an outbreak of infectious diseases due to high-density farming. Antibiotic overuse and misuse in fish farming and its global health consequences have led to searching for more natural alternatives such as medicinal plants. In this sense, garlic (Allium sativum) has different bioactive compounds with biological properties for animal health. Among them are the ajoene, alliin, and allicin, which confer biological properties such as growth promotion, antimicrobial, antiviral, antioxidant, and antiparasitic. Ways to use garlic in aquaculture include oil, fresh mash, aqueous extract, and garlic powder. The powder presentation is the most used in aquaculture; it is generally applied by oral administration, adding to the feed, and the dose used ranges from 0.05 to 40 g/kg of feed. Garlic has been used in the aquaculture of different species such as rainbow trout (Oncorhynchus mykiss), spotted grouper (Epinephelus coioides), catfish (Clarias gariepinus), tilapia (Oreochromis niloticus), guppy fish (Poecilia reticulata), goldfish (Carassius auratus), and barramundi (Lates calcarifer). In addition to its properties, garlic’s usage became popular, thanks to its low cost, easy incorporation into food, and little environmental impact. Therefore, its application can be an effective solution to combat diseases, improve organisms’ health using natural supplies, and as an alternative to antibiotics. This review reports and discusses plant-derived products’ beneficial properties, emphasizing garlic and its usages in fish aquaculture.
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References
Abd El-Galil MA, Aboelhadid SM (2012) Trials for the control of trichodinosis and gyrodactylosis in hatchery reared Oreochromis niloticus fries by using garlic. Vet Parasitol 185:57–63. https://doi.org/10.1016/j.vetpar.2011.10.035
Abdel-Tawwab M, Khalifa E, Diab AM, Khallaf MA, Abdel-Razek N, Khalil RHJAI (2020) Dietary garlic and chitosan alleviated zearalenone toxic effects on performance, immunity, and challenge of European sea bass, Dicentrarchus labrax, to Vibrio alginolyticus infection 28:493-510
Adineh H, Harsij M, Jafaryan H, Asadi M (2020) The effects of microencapsulated garlic (Allium sativum) extract on growth performance, body composition, immune response and antioxidant status of rainbow trout (Oncorhynchus mykiss) juveniles. J Appl Anim Res 48:372–378. https://doi.org/10.1080/09712119.2020.1808473
Agus Putra A, Santoso U, Lee M, Nan F (2013) Effects of dietary katuk leaf extract on growth performance, feeding behavior and water quality of grouper Epinephelus coioides. Aceh Int J Sci Technol 2:17-25. https://doi.org/10.13170/aijst.2.1.488
Akhter N, Wu B, Memon AM, Mohsin M (2015) Probiotics and prebiotics associated with aquaculture: a review. Fish Shellfish Immunol 45:733–741. https://doi.org/10.1016/j.fsi.2015.05.038
Alexander CP, Kirubakaran CJW, Michael RD (2010) Water soluble fraction of Tinospora cordifolia leaves enhanced the non-specific immune mechanisms and disease resistance in Oreochromis mossambicus. Fish Shellfish Immunol 29:765–772. https://doi.org/10.1016/j.fsi.2010.07.003
Altinterim B, Aksu O (2019) Masere sarımsak (Allium sativum Limne) ve Tunceli sarımsağı (Allium tuncelianum Kollman) yağlarının yoğun stoklanmış gökkuşağı alabalıklarının (Oncorhynchus mykiss W.) bazı kan parametrelerine ve NBT (Nitroblue Tetrazolium) seviyelerine etkileri Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21:716–723
Aly SM, Atti NMA (2008) Effect of garlic on the survival, growth, resistance and quality of Oreochromis niloticus In: 8th International Symposium on Tilapia in Aquaculture, Cairo, Egypt, October 12–14, 2008. pp 277–296
Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y (2001) Intake of garlic and its bioactive components. J Nutr 131:955s–962s
Ankri S, Mirelman D (1999) Antimicrobial properties of allicin from garlic. Microbes Infect 1:125–129. https://doi.org/10.1016/S1286-4579(99)80003-3
Anthony JP, Fyfe L, Smith H (2005) Plant active components—a resource for antiparasitic agents? Trends Parasitol 21:462–468. https://doi.org/10.1016/j.pt.2005.08.004
Anton R (2016) Les constituants spécifiques des Alliaceae. Phytothérapie 14:149–153. https://doi.org/10.1007/s10298-016-1043-6
Awad E, Awaad A (2017) Role of medicinal plants on growth performance and immune status in fish. Fish Shellfish Immunol 67:40–54. https://doi.org/10.1016/j.fsi.2017.05.034
Bakri IM, Douglas CWI (2005) Inhibitory effect of garlic extract on oral bacteria. Arch Oral Biol 50(7):645–651
Balasubramanian G, Sarathi M, Venkatesan C, Thomas J, Sahul Hameed AS (2008) Oral administration of antiviral plant extract of Cynodon dactylon on a large scale production against White spot syndrome virus (WSSV) in Penaeus monodon. Aquaculture 279:2–5. https://doi.org/10.1016/j.aquaculture.2008.03.052
Banerjee G, Ray AK (2017) The advancement of probiotics research and its application in fish farming industries. Res Vet Sci 115:66–77. https://doi.org/10.1016/j.rvsc.2017.01.016
Bayan L, Koulivand PH, Gorji A (2014) Garlic: a review of potential therapeutic effects. Avicenna J Phytomed 4:1–14. https://doi.org/10.22038/ajp.2014.1741
Bender-Bojalil D, Bárcenas-Pozos ME (2013) El ajo y sus aplicaciones en la conservación de alimentos Temas Selectos de Ingeniería de Alimentos 7:25-36
Block E (1985) Chemistry of garlic and onions. Sci Am 252:94–99
Bonder MJ, Tigchelaa EF, Cai X, Trynka G, Cenit MC, Hrdlickova B et al (2016) The influence of a short-term gluten-free diet on the human gut microbiome. Genome Med 8:45. https://doi.org/10.1186/s13073-016-0295-y
Borlinghaus J, Albrecht F, Gruhlke MC, Nwachukwu ID, Slusarenko AJ (2014) Allicin: chemistry and biological properties. Molecules 19:12591–12618. https://doi.org/10.3390/molecules190812591
Breyer KE, Getchell RG, Cornwell ER, Wooster GA, Ketola HG, Bowser PR (2015) Efficacy of an extract from garlic, Allium sativum, against infection with the Furunculosis bacterium, Aeromonas salmonicida, in rainbow trout, Oncorhynchus mykiss. J World Aquacult Soc 46:273–282. https://doi.org/10.1111/jwas.12218
Bruck R, Aeed H, Brazovsky E, Noor T, Hershkoviz R (2005) Allicin, the active component of garlic, prevents immune-mediated, concanavalin A-induced hepatic injury in mice. Liver Int 25:613–621. https://doi.org/10.1111/j.1478-3231.2005.01050.x
Campelo DAV, Gonçalves IS, De Moura LB, Brabo MF, Barbas LAL, Veras GC (2020). Dietary garlic essential oil on development parameters of severum post-larvae. Rev Bras Saúde Produção Anim 21
Carbajal-González MT, Fregeneda-Grandes JM, Suárez-Ramos S, Rodríguez Cadenas F, Aller-Gancedo JM (2011) Bacterial skin flora variation and in vitro inhibitory activity against Saprolegnia parasitica in brown and rainbow trout. Dis Aquat Org 96:125–135. https://doi.org/10.3354/dao02391
Carbone D, Faggio C (2016) Importance of prebiotics in aquaculture as immunostimulants Effects on immune system of Sparus aurata and Dicentrarchus labrax. Fish Shellfish Immunol 54:172–178. https://doi.org/10.1016/j.fsi.2016.04.011
Chandrashekar PM, Venkatesh YP (2012) Fructans from aged garlic extract produce a delayed immunoadjuvant response to ovalbumin antigen in BALB/c mice. Immunopharmacol Immunotoxicol 34:174–180. https://doi.org/10.3109/08923973.2011.584066
Chanu TI, Sharma A, Roy SD, Chaudhuri AK, Biswas P (2012) Herbal biomedicine—an alternative to synthetic chemicals in aquaculture feed in Asia. World Aquacult 43:14–16
Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW (2003) Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361:2045–2046. https://doi.org/10.1016/S0140-6736(03)13615-X
Citarasu T (2010) Herbal biomedicines: a new opportunity for aquaculture industry. Aquacult Int 18:403–414. https://doi.org/10.1007/s10499-009-9253-7
Cross ML (2002) Microbes versus microbes: immune signals generated by probiotic. FEMS Immunol Med Microbiol 34:245–253
Cunha JA, Heizmann BM, Baldisserotto B (2018) The effects of essential oils and their major compounds on fish bacterial pathogens—a review. J Appl Microbiol 125:328–344. https://doi.org/10.1111/jam.13911
Darbyshire B, Henryf RJ (1981) Differences in fructan content and synthesis in some Allium species. New Phytol 87:249–256
Dawood MAO, Koshio S (2016) Recent advances in the role of probiotics and prebiotics in carp aquaculture: a review. Aquaculture 454:243–251. https://doi.org/10.1016/j.aquaculture.2015.12.033
Dehler CE, Secombes CJ, Martin SAM (2017) Environmental and physiological factors shape the gut microbiota of Atlantic salmon parr (Salmo salar L.). Aquaculture 467:149–157. https://doi.org/10.1016/j.aquaculture.2016.07.017
Drago Serrano ME, López López M, Saínz Espuñes TDR (2006) Componentes bioactivos de alimentos funcionales de origen vegetal. Rev Mex Cienc Farmaceuticas 37:58–68
Eirna-liza N, Saad CR, Hassim HA, Karim M (2016) The effects of dietary inclusion of garlic on growth performance and disease resistance of African catfish (Clarias gariepinus) fingerlings against Aeromonas hydrophila infection. J Environ Biol 37:817–824. https://doi.org/10.4324/9780203137574
El-dougdoug KA, Sofy AR, Mousa AA, Sofy MR, Hmed AA, Abbas AA (2018) Safe and efficacious anti-cytomegalovirus agents with therapeutic activity in vitro. J Microbiol Res 8:33–42. https://doi.org/10.5923/j.microbiology.20180802.02
Erguig MYH, Fekhaoui M, Dakki M (2015) The use of garlic in aquaculture. Eur J Biotechnol Biosci 3:28–33
Esquivel-Elizondo S, Ilhan ZE, Garcia-Penã EI, Krajmalnik-Brown R (2017) Insights into butyrate production in a controlled fermentation system via gene predictions. mSystems 2:e00051-e117
Etyemez Büyükdeveci M et al (2018) Effects of garlic-supplemented diet on growth performance and intestinal microbiota of rainbow trout (Oncorhynchus mykiss). Aquaculture 486:170–174. https://doi.org/10.1016/j.aquaculture.2017.12.022
FAO (2020) El estado mundial de la pesca y la acuicultura 2020. La sostenibilidad en acción 243. https://doi.org/10.4060/ca9229es
Ferreira-Halder CV, de Sousa Faria AV, Andrade SS (2017) Action and function of Faecalibacterium prausnitzii in health and disease. Best Pract Res Clin Gastroenterol 31:643–648. https://doi.org/10.1016/j.bpg.2017.09.011
Forwood JM, Harris JO, Deveney MR (2013) Efficacy of current and alternative bath treatments for Lepidotrema bidyana infecting silver perch Bidyanus bidyanus. Aquaculture 416–417:65–71. https://doi.org/10.1016/j.aquaculture.2013.08.034
Foysal MJ et al (2019) Dietary supplementation of garlic (Allium sativum) modulates gut microbiota and health status of tilapia (Oreochromis niloticus) against Streptococcus iniae infection. Aquacult Res 50:2107–2116. https://doi.org/10.1111/are.14088
Freeman F, Kodera Y (1995) Garlic chemistry: stability of S-(2-propenyl)-2-propene-1-sulfinothioate (allicin) in blood, solvents, and simulated physiological fluids. J Agric Food Chem 43(9):2332–2338
Fridman S, Sinai T, Zilberg D (2014) Efficacy of garlic based treatments against monogenean parasites infecting the guppy (Poecilia reticulata (Peters)). Vet Parasitol 203:51–58. https://doi.org/10.1016/j.vetpar.2014.02.002
Gabriel NN, Wilhelm MR, Habte-Tsion HM, Chimwamurombe P, Omoregie E (2019) Dietary garlic (Allium sativum) crude polysaccharides supplementation on growth, haematological parameters, whole body composition and survival at low water pH challenge in African catfish (Clarias gariepinus) juveniles. Scientific African 5:e00128
Gajardo K, Jaramillo-Torres A, Kortner TM, Merrifield DL, Tinsley J, Bakke AM, Krogdahl A (2017) Alternative protein sources in the diet modulate microbiota and functionality in the distal intestine of Atlantic salmon (Salmo salar). Appl Environ Microbiol 83(5):1–16. https://doi.org/10.1128/AEM.02615‐16
Gambogou B, Anani K, Karou SD, Ameyapoh YA, Simpore J (2018a) Effect of aqueous garlic extract on biofilm formation and antibiotic susceptibility of multidrug-resistant uropathogenic Escherichia coli clinical isolates in Togo. Int J Adv Multidiscip Res 5:23–33. https://doi.org/10.22192/ijamr
Gambogou B, Ouattara A, Taale E, Karou S, Ameyapoh Y, Simpore J (2018b) Garlic as alternative therapy to treat uropathogene bacteria in women with urinary tract infection in Lomé Togo. Eur J Pharm Med Res 5:1–7
Ganguly S, Dora KC, Sarkar S, Chowdhury S (2013) Supplementation of prebiotics in fish feed: a review. Rev Fish Biol Fish 23:195–199. https://doi.org/10.1007/s11160-012-9291-5
Gbekley HE, Karou SD, Katawa G, Tchacondo T, Batawila K, Ameyapoh Y, Simpore J (2018) Ethnobotanical survey of medicinal plants used in the management of hypertension in the maritime region of Togo African. J Tradit Complement Altern Med 15:85–97. https://doi.org/10.21010/ajtcam.vi15.1.9
Gismondo MR, Drago L, Lombardi A (1999) Review of probiotics available to modify gastrointestinal flora. Int J Antimicrob Agents 12:287–292
Gökalp F (2018) The inhibition effect of garlic-derived compounds on human immunodeficiency virus type 1 and saquinavir. J Biochem Mol Toxicol 32:e22215–e22215. https://doi.org/10.1002/jbt.22215
González Maza M, Guerra Ibañez G, Maza Hernández JC, Cruz Dopico A (2014) Revisión bibliográfica sobre el uso terapéutico del ajo. Rev Cubana Med Fis Rehabil 6:61–71
Guerreiro I, Oliva-Teles A, Enes P (2018) Prebiotics as functional ingredients: focus on Mediterranean fish aquaculture. Rev Aquac 10:800–832. https://doi.org/10.1111/raq.12201
Guo JJ, Kuo CM, Chuang YC, Hong JW, Chou RL, Chen TI (2012) The effects of garlic-supplemented diets on antibacterial activity against Streptococcus iniae and on growth in orange-spotted grouper Epinephelus coioides. Aquaculture 364–365:33–38. https://doi.org/10.1016/j.aquaculture.2012.07.023
Guo JJ, Kuo CM, Hong JW, Chou RL, Lee YH, Chen TI (2015) The effects of garlic-supplemented diets on antibacterial activities against Photobacterium damselae subsp. piscicida and Streptococcus iniae and on growth in Cobia Rachycentron canadum. Aquaculture 435:111–115. https://doi.org/10.1016/j.aquaculture.2014.09.029
Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui Y, Ang CYW (2005) Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John’s Wort, garlic oil Panax ginseng and Ginkgo biloba. Drugs Aging 22:525–539. https://doi.org/10.2165/00002512-200522060-00006
Hai NV (2015) The use of probiotics in aquaculture. J Appl Microbiol 119:917–935. https://doi.org/10.1111/jam.12886
Harris JC, Cottrell SL, Plummer S, Lloyd D (2001) Antimicrobial properties of Allium sativum (garlic). Appl Microbiol Biotechnol 57(3):282–286
Hernández-Contreras Á, Hernández MD (2020) Application of aromatic plants and their extracts in aquaculture. In: Feed Additives. pp 239–259. https://doi.org/10.1016/b978-0-12-814700-9.00014-5
Hoseinifar SH, Van Doan H, Dadar M, Ringo E, Harikrishnan R (2019) Feed additives, gut microbiota, and health in finfish aquaculture. In Microbial communities in aquaculture ecosystems (pp. 121–142). Cham: Springer
Huang AG, Yi YL, Ling F, Lu L, Zhang QZ, Wang GX (2013) Screening of plant extracts for anthelmintic activity against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Parasitol Res 112:4065–4072. https://doi.org/10.1007/s00436-013-3597-7
Iberl B, Winkler G, Knobloch K (1990a) Products of allicin transformation: ajoenes and dithiins, characterization and their determination by HPLC. Planta Med 56(02):202–211
Iberl B, Winkler G, Müller B, Knobloch K (1990b) Quantitative determination of allicin and alliin from garlic by HPLC. Planta Med 56(03):320–326
Ibrahim M et al. (2020) Current trends of antimicrobials used in food animals and aquaculture. In: Antibiotics and Antimicrobial Resistance Genes in the Environment. pp 39–69. https://doi.org/10.1016/b978-0-12-818882-8.00004-8
Imai J, Ide N, Nagae S, Moriguchi T, Matsuura H, Itakura Y (1994) Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Med 60(05):417–420
Jakobsen TH et al (2012) Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob Agents Chemother 56:2314–2325. https://doi.org/10.1128/AAC.05919-11
Ji J, Lu C, Kang Y, Wang GX, Chen P (2012) Screening of 42 medicinal plants for in vivo anthelmintic activity against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Parasitol Res 111:97–104
Jonkers D, van den Broek E, van Dooren I, Thijs C, Dorant E, Hageman G, Stobberingh E (1999) Antibacterial effect of garlic and omeprazole on Helicobacter pylori. J Antimicrob Chemother 43:837–839. https://doi.org/10.1093/jac/43.6.837
Karimi Pashaki A, Ghasemi M, Zorriehzahra J, Sharif Rohani M, Hosseini S (2020) Effects of dietary garlic (Allium sativum) extract on survival rate, blood and immune parameters changes and disease resistance of Common carp (Cyprinus carpio carpio Linnaeus, 1758) against Spring Viremia of Carp (SVC). Iran J Fish Sci 19:1024–1039. https://doi.org/10.22092/ijfs.2020.120999
Kavitha C, Ramesh M, Kumaran SS, Lakshmi SA (2012) Toxicity of Moringa oleifera seed extract on some hematological and biochemical profiles in a freshwater fish Cyprinus carpio. Exp Toxicol Pathol 64:681–687. https://doi.org/10.1016/j.etp.2011.01.001
Klimpel S, Abdel-Ghaffar F, Al-Rasheid KAS, Aksu G, Fischer K, Strassen B, Mehlhorn H (2011) The effects of different plant extracts on nematodes. Parasitol Res 108:1047–1054. https://doi.org/10.1007/s00436-010-2168-4
Kumolu-Johnson CA, Ndimele PE, Olasehinde FI (2012) Preliminary study on the antioxidative and antimicrobial effects of fresh garlic (Allium sativum) on the shelf life of hot-smoked catfish (Clarias gariepinus). J Fish Aquat Sci 8:253–256. https://doi.org/10.3923/jfas.2013.253.256
Lang A et al (2004) Allicin inhibits spontaneous and TNF-a induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr 23:1199–1208. https://doi.org/10.1016/j.clnu.2004.03.011
Lawson LD (1993) Bioactive organosulfur compounds of garlic and garlic products: role in reducing blood lipids 306–330
Lawson LD (1998) Garlic: a review of its medicinal effects and indicated active compounds. Blood 179:62
Lawson LD, Hughes BG (1992) Characterization of the formation of allicin and other thiosulfinates from garlic. Planta Med 58(04):345–350
Lazado CC, Caipang CMA (2014) Mucosal immunity and probiotics in fish. Fish Shellfish Immunol 39:78–89. https://doi.org/10.1016/j.fsi.2014.04.015
Lee GY (2012) Review of the application of garlic, Allium sativum, in aquaculture. J World Aquacult Soc 43:447–458. https://doi.org/10.1111/j.1749-7345.2012.00581.x
Lee DH, Lim SR, Han JJ, Lee SW, Ra CS, Kim JD (2014) Effects of dietary garlic powder on growth, feed utilization and whole body composition changes in fingerling sterlet sturgeon Acipenser ruthenus. Asian-Australas J Anim Sci 27:1303–1310. https://doi.org/10.5713/ajas.2014.14087
Li M, Muthaiyan A, O’Bryan CA, Gustafson JE, Li Y, Crandall PG, Ricke SC (2011) Use of natural antimicrobials from a food safety perspective for control of Staphylococcus aureus. Curr Pharm Biotechnol 12:1240–1254. https://doi.org/10.2174/138920111796117283
Lillehoj H, Liu Y, Calsamiglia S, Fernández-Miyakawa ME, Chi F, Craven RL et al (2018) Phytochemicals as antibiotic alternatives to promote growth and enhance host health. Vet Res 49:1–18. https://doi.org/10.1186/s13567-018-0562-6
Liu J et al (2018) Investigation of the dynamic changes in the chemical constituents of Chinese “laba” garlic during traditional processing. RSC Adv 8:41872–41883. https://doi.org/10.1039/c8ra09657k
López MT (2007) El ajo propiedades farmacológicas e indicaciones terapéuticas. OFFARM 26(1):79–81
Manoppo Gpeogoc H, Kolopita MEF, Malatunduh R (2016) Growth promoter effect of garlic (Allium sativum) on carp (Cyprinus carpio L.). Int J PharmTech Res 9:283–288
Metwally M (2009) Effects of garlic (Allium sativum) on some antioxidant activities in tilapia nilotica (Oreochromis niloticus). World J Fish Marine Sci 1:56–64
Michl SC, Ratten JM, Beyer M, Hasler M, LaRoche J, Schulz C (2017) The malleable gut microbiome of juvenile rainbow trout (Oncorhynchus mykiss): diet‐dependent shifts of bacterial community structures. PLoS ONE 12(5):e0177735. https://doi.org/10.1371/journal.pone.0177735
Mikaili P, Maadirad S, Moloudizargari M, Aghajanshakeri S, Sarahroodi S (2013) Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds. Iran J Basic Med Sci 16(10):1031
Militz TA, Southgate PC, Carton AG, Hutson KS (2013) Dietary supplementation of garlic (Allium sativum) to prevent monogenean infection in aquaculture. Aquaculture 408–409:95–99. https://doi.org/10.1016/j.aquaculture.2013.05.027
Militz TA, Southgate PC, Carton AG, Hutson KS (2014) Efficacy of garlic (Allium sativum) extract applied as a therapeutic immersion treatment for Neobenedenia sp. management in aquaculture. J Fish Dis 37:451–461. https://doi.org/10.1111/jfd.12129
Miron T, Rabinkov A, Mirelman D, Wilchek M, Weiner L (2000) The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity. Biochim Biophys Acta (BBA) Biomembr 1463(1):20–30
Miron T, Bercovici T, Rabinkov A, Wilchek M, Mirelman D (2004) [3H]Allicin: preparation and Applications. Anal Biochem 331(2):364–369
Mohan K et al (2019) Application of marine-derived polysaccharides as immunostimulants in aquaculture: a review of current knowledge and further perspectives. Fish Shellfish Immunol 86:1177–1193. https://doi.org/10.1016/j.fsi.2018.12.072
Mohebbi A, Nematollahi A, Dorcheh EE, Asad FG (2012) Influence of dietary garlic (Allium sativum) on the antioxidative status of rainbow trout (Oncorhynchus mykiss). Aquacult Res 43:1184–1193. https://doi.org/10.1111/j.1365-2109.2011.02922.x
Mona MH, Rizk E-ST, Salama WM, Younis ML (2015) Efficacy of probiotics, prebiotics, and immunostimulant on growth performance and immunological parameters of Procambarus clarkii juveniles. J Basic Appl Zool 69:17–25. https://doi.org/10.1016/j.jobaz.2015.07.002
Motlagh HA, Safari O, Selahvarzi Y, Baghalian A, Kia E (2020) Non-specific immunity promotion in response to garlic extract supplemented diets in female Guppy (Poecilia reticulata). Fish Shellfish Immunol 97:96–99
Musa N, Wei LS, Seng CT, Wee W, Leong LK (2008) Potential of edible plants as remedies of systemic bacterial disease infection in cultured fish. Global J Pharmacol 2:31–36
Nayak SK (2010) Role of gastrointestinal microbiota in fish. Aquac Res 41(11):1553–1573
Ndong D, Fall J (2011) The effect of garlic (Allium sativum) on growth and immune responses of hybrid tilapia (Oreochromis niloticus x Oreochromis aureus). J Clin Immunol Immunopathol Res 3:1–9
Newaj-Fyzul A, Austin B (2015) Probiotics, immunostimulants, plant products and oral vaccines, and their role as feed supplements in the control of bacterial fish diseases. J Fish Dis 38:937–955. https://doi.org/10.1111/jfd.12313
Nya EJ, Austin B (2009b) Use of garlic, Allium sativum, to control Aeromonas hydrophila infection in rainbow trout, Oncorhynchus mykiss (Walbaum). J Fish Dis 32:963–970. https://doi.org/10.1111/j.1365-2761.2009.01100.x
Nya EJ, Dawood Z, Austin B (2010) The garlic component, allicin, prevents disease caused by Aeromonas hydrophila in rainbow trout, Oncorhynchus mykiss (Walbaum). J Fish Dis 33:293–300. https://doi.org/10.1111/j.1365-2761.2009.01121.x
Nyman A, Huyben D, Lundh T, Dicksved J (2017) Effects of microbe‐ and mussel‐based diets on the gut microbiota in Arctic charr (Salvelinus alpinus). Aquacult Rep 5:34–40. https://doi.org/10.1016/j.aqrep.2016.12.003
Oosthuizen CB, Reid A-M, Lall N (2018) Garlic (Allium sativum) and its associated molecules, as medicine. In: Lall N (ed) Medicinal Plants for Holistic Health and Well-Being. Amsterdam: Elsevier Inc, pp 277–295. https://doi.org/10.1016/b978-0-12-812475-8.00009-3
Parker RB (1974) Probiotics, the other half of the antibiotic story. Anim Nutr Health 29:4–8
Pérez T, Balcázar JL, Ruiz-Zarzuela I, Halaihel N, Vendrell D, De Blas I, Múzquiz JL (2010) Host–microbiota interactions within the fish intestinal ecosystem. Mucosal Immunol 3(4):355–360
Pérez-Sánchez T, Mora-Sánchez B, Balcázar JL (2018) Biological approaches for disease control in aquaculture: advantages, limitations and challenges. Trends Microbiol 26:896–903. https://doi.org/10.1016/j.tim.2018.05.002
Prieto A, Ocampo AD, Fernández A, Pérez MB (2005) The use of natural medicine in the control of aquatic organism diseases and the potentiality of its utilization in Cuba and Mexico. TIP Rev Especializada Ciencias Químico Biológicas 8(1):38–49
Pryde SE, Duncan SH, Hold GL, Stewart CS, Harry JF (2002) The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett 217:133–139
Raman RP (2017) Applicability, feasibility and efficacy of phytotherapy in aquatic animal health management. Am J Plant Sci 08:257–287. https://doi.org/10.4236/ajps.2017.82019
Reverter M, Bontemps N, Lecchini D, Banaigs B, Sasal P (2014) Use of plant extracts in fish aquaculture as an alternative to chemotherapy: current status and future perspectives. Aquaculture 433:50–61. https://doi.org/10.1016/j.aquaculture.2014.05.048
Reverter M, Tapissier-Bontemps N, Sasal P, Saulnier D (2017) Use of medicinal plants in aquaculture. In: Diagnosis and Control of Diseases of Fish and Shellfish. pp 223–261. https://doi.org/10.1002/9781119152125.ch9
Reverter M et al (2020) Aquaculture at the crossroads of global warming and antimicrobial resistance. Nat Commun 11:1870. https://doi.org/10.1038/s41467-020-15735-6
Reverter M, Tapissier-Bontemps N, Sarter S, Sasal P, Caruso D (2021) Moving towards more sustainable aquaculture practices: a meta-analysis on the potential of plant-enriched diets to improve fish growth, immunity and disease resistance 13:537–555. https://doi.org/10.1111/raq.12485
Rimoldi S, Finzi G, Ceccotti C, Girardello R, Grimaldi A, Ascione C et al (2016) Butyrate and taurine exert a mitigating effect on the inflamed distal intestine of European sea bass fed with a high percentage of soybean meal. Fish Aquat Sci 19:40. https://doi.org/10.1186/s41240-016-0041-9
Rimoldi S, Torrecillas S, Montero D, Gini E, Makol A, Valdenegro VV et al (2020) Assessment of dietary supplementation with galactomannan oligosaccharides and phytogenics on gut microbiota of European sea bass (Dicentrarchus Labrax) fed low fishmeal and fish oil based diet. PLoS ONE 15(4):e0231494
Ringo E, Strom E, Tabachek JA (1995) Intestinal microflora of salmonids: a review. Aquac Res 26(10):773–789
Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I et al (2010) Prebiotic effects: metabolic and health benefits. British J Nutr 104:S1–S63. https://doi.org/10.1017/S0007114510003363
Rodgers CJ, Furones MD (2009) Antimicrobial agents in aquaculture: practice, needs and issues. In: Rodgers C, Basurco B (eds) The use of veterinary drugs and vaccines in Mediterranean aquaculture, vol 86. vol A. Zaragoza: CIHEAM, pp 41–59. https://doi.org/10.13140/2.1.4697.0560
Saha M, Bandyopadhyay PK (2017) Phytochemical screening for identification of bioactive compound and antiprotozoan activity of fresh garlic bulb over trichodinid ciliates affecting ornamental goldfish. Aquaculture 473:181–190. https://doi.org/10.1016/j.aquaculture.2017.02.009
Saif S, Hanif MA, Rehman R, Riaz M (2020) Chapter 23 - Garlic. In: Hanif MA, Nawaz H, Khan MM, Byrne HJ (eds) Medicinal Plants of South Asia. Elsevier, pp 301–315. https://doi.org/10.1016/B978-0-08-102659-5.00023-9
Sakai M (1999) Current research status of fish immunostimulants. Aquaculture 172(1–2):63–92
Sakata T (1990) Microflora in the digestive tract of fish and shellfish. In: Lesel R (ed) Microbiology in Poecilotherms. Amsterdam: Elsevier, pp 171–176
Samson JS (2019) Effect of garlic (Allium sativum) supplemented diets on growth, feed utilization and survival of red tilapia (Oreochromis sp.). Technology 15(4):637–644
Sasmal D, Babu CS, Abraham TJ (2005) Effect of garlic (Allium sativum) extract on the growth and disease resistance of Carassius auratus (Linnaeus, 1758). Indian J Fish 52(2):207–214
Semova I, Carten JD, Stombaugh J, Mackey LC, Knight R, Farber SA, Rawls JF (2012) Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish. Cell Host Microbe 12(3):277–288. https://doi.org/10.1016/j.chom.2012.08.003
Shakya SR, Labh SN (2014) Medicinal uses of garlic (Allium sativum) improves fish health and acts as an immunostimulant in aquaculture. Eur J Biotechnol Biosci 2:44–47
Shang A et al (2019) Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods 8:246–246. https://doi.org/10.3390/foods8070246
Sharma N (2019) Assessment of potential use of garlic (Allium sativum) against growth of microbes. Int J Res Pharm Sci 10:3508–3515
Singh R, Singh K (2019) Garlic: a spice with wide medicinal actions. J Pharmacogn Phytochem 8:1349–1355
Soffar SA, Mokhtar GM (1991) Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in Hymenolepiasis nana and giardiasis. J Egypt Soc Parasitol 21:497–502
Soliman WS, Shaapan RM, Mohamed LA, Gayed SSR (2019) Recent biocontrol measures for fish bacterial diseases, in particular to probiotics, bio-encapsulated vaccines, and phage therapy. Open Vet J 9:190–195. https://doi.org/10.4314/ovj.v9i3.2
Song SK, Beck BR, Kim D, Park J, Kim J, Kim HD, Ringø E (2014) Prebiotics as immunostimulants in aquaculture: a review. Fish Shellfish Immunol 40:40–48. https://doi.org/10.1016/j.fsi.2014.06.016
Stentiford GD et al (2012) Disease will limit future food supply from the global crustacean fishery and aquaculture sectors. J Invertebr Pathol 110:141–157. https://doi.org/10.1016/j.jip.2012.03.013
Subramanian MS, Nandagopal Ms G, Amin Nordin S, Thilakavathy K, Joseph N (2020) Prevailing knowledge on the bioavailability and biological activities of sulphur compounds from alliums: a potential drug candidate. Molecules 25(18):4111. https://doi.org/10.3390/molecules25184111
Syahidah A, Saad CR, Daud HM, Abdelhadi YM (2015) Status and potential of herbal applications in aquaculture: a review. Iran J Fish Sci 14:27–44
Syngai G, Dey S, Bharali R (2016) Evaluation of toxicity levels of the aqueous extract of Allium sativum and its effects on the behavior of juvenile common carp (Cyprinus carpio L., 1758). Evaluation 9(3)
Szychowski KA et al (2018) Characterization of active compounds of different garlic (Allium sativum L.) Cultivars. Polish J Food Nutr Sci 68:73–81. https://doi.org/10.1515/pjfns-2017-0005
Tafalla C, Bøgwald J, Dalmo RA (2013) Adjuvants and immunostimulants in fish vaccines: current knowledge and future perspectives. Fish Shellfish Immunol 35:1740–1750. https://doi.org/10.1016/j.fsi.2013.02.029
Talpur AD, Ikhwanuddin M (2012) Dietary effects of garlic (Allium sativum) on haemato-immunological parameters, survival, growth, and disease resistance against Vibrio harveyi infection in Asian sea bass, Lates calcarifer (Bloch). Aquaculture 364–365:6–12. https://doi.org/10.1016/j.aquaculture.2012.07.035
Tanekhy M, Fall J (2015) Expression of innate immunity genes in kuruma shrimp Marsupenaeus japonicus after in vivo stimulation with garlic extract (allicin) Veterinární Medicína 60:39–47. https://doi.org/10.17221/7924-vetmed
Tazikeh T, Abedian Kenari A, Esmaeili M (2020) Effects of fish meal replacement by meat and bone meal supplemented with garlic (Allium sativum) powder on biological indices, feeding, muscle composition, fatty acid and amino acid profiles of whiteleg shrimp (Litopenaeus vannamei). Aquacult Res 51:674–686. https://doi.org/10.1111/are.14416
Thanikachalam K, Kasi M, Rathinam X (2010) Effect of garlic peel on growth, hematological parameters and disease resistance against Aeromonas hydrophila in African catfish Clarias gariepinus(Bloch) fingerlings. Asian Pacific J Trop Med 3:614–618. https://doi.org/10.1016/S1995-7645(10)60149-6
Torrecillas S et al (2019) Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation. PLoS ONE 14:e0222063. https://doi.org/10.1371/journal.pone.0222063
Umeda N, Nibe H, Hara T, Hirazawa N (2006) Effects of various treatments on hatching of eggs and viability of oncomiracidia of the monogenean Pseudodactylogyrus anguillae and Pseudodactylogyrus bini. Aquaculture 253:148–153. https://doi.org/10.1016/j.aquaculture.2005.08.009
Vallejo Villalobos JR, Peral Pacheco D, Carrasco Ramos MC (2008) Las especies del género Allium con interés medicinal en Extremadura. Med Naturista 2:2–6
Vallejos-Vidal E, Reyes-López F, Teles M, MacKenzie S (2016) The response of fish to immunostimulant diets. Fish Shellfish Immunol 56:34–69. https://doi.org/10.1016/j.fsi.2016.06.028
Van Hai N (2015) The use of medicinal plants as immunostimulants in aquaculture: a review. Aquaculture 446:88–96. https://doi.org/10.1016/j.aquaculture.2015.03.014
Vásquez-Piñeros M, Rondón-Barragan I, Eslava-Mocha PR (2012) Imunoestimulantes em teleósteos : Probióticos, Beta-glucanas e LPS Orinoquia 16:46-62
Villanueva-Gutiérrez E, Martínez-Córdova LR, Martínez-Porchas M, Arvayo MA (2015) Effect of the addition of an aqueous extract of the San Pedro Daisy Lasianthaea podocephala, in the culture of the Pacific white shrimp Litopenaeus vannamei, under laboratory conditions. Latin Am J Aquat Res 43:904–911
Vuddhakul V, Bhoopong P, Hayeebilan F, Subhadhirasakul S (2007) Inhibitory activity of Thai condiments on pandemic strain of Vibrio parahaemolyticus. Food Microbiol 24(4):413–418
Wada T, Arima T, Nagashima H (1987) Natural killer activity in patients with chronic hepatitis treated with Ok432, interferon, adenine arabinoside and glycyrrhizin. Gastroenterol Jpn 22:312–321. https://doi.org/10.1007/BF02774257
Walker AW, Ince J, Duncan SH, Webster LM, Holtrop G, Ze X et al (2011) Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J 5(2):220–230. https://doi.org/10.1038/ismej.2010.118
Walther TC, Farese RV Jr (2012) Lipid droplets and cellular lipid metabolism. Annu Rev Biochem 81:687–714
Wang A et al (2019) Use of probiotics in aquaculture of China—a review of the past decade. Fish Shellfish Immunol 86:734–755. https://doi.org/10.1016/j.fsi.2018.12.026
Wang C, Sun G, Li S, Li X, Liu Y (2017) Intestinal microbiota of healthy and unhealthy Atlantic salmon Salmo salar L. in a recirculating aquaculture system. Chin J Oceanol Limnol 36(2):1–13. https://doi.org/10.1007/s00343‐017‐6203‐5
Weinberg DS, Manier ML, Richardson MD, Haibach FG (1993) Identification and quantification of organosulfur compliance markers in a garlic extract. J Agric Food Chem 41(1):37–41
Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ (2006) Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40(3):235–243. https://doi.org/10.1097/00004836-200603000-00015
Wu CC, Liu CH, Chang YP, Hsieh SL (2010) Effects of hot-water extract of Toona sinensis on immune response and resistance to Aeromonas hydrophila in Oreochromis mossambicus. Fish Shellfish Immunol 29:258–263. https://doi.org/10.1016/j.fsi.2010.04.021
Yan X, Wang Z, Barlow P (1992) Quantitative estimation of garlic oil content in garlic oil based health products. Food Chem 45(2):135–139
Yun HM, Ban JO, Park KR, Lee CK, Jeong HS, Han SB, Hong JT (2014) Potential therapeutic effects of functionally active compounds isolated from garlic. Pharmacol Ther 142:183–195. https://doi.org/10.1016/j.pharmthera.2013.12.005
Zaineldin AI et al (2018) Bacillus subtilis as probiotic candidate for red sea bream: growth performance, oxidative status, and immune response traits. Fish Shellfish Immunol 79:303–312. https://doi.org/10.1016/j.fsi.2018.05.035
Zaki MA, Labib EM, Nour AM, Tonsy HD, Mahmoud SH (2012) Effect of some medicinal plants diets on the mono-sex Nile Tilapia (Oreochromis niloticus), growth performance, feed utilization and some physiological parameters. Egypt J Aquat Biol Fish 4:220–227. https://doi.org/10.21608/ejabf.2011.2101
Zardast M, Namakin K, Esmaelian Kaho J, Hashemi SS (2016) Assessment of antibacterial effect of garlic in patients infected with Helicobacter pylori using urease breath test. Avicenna J Phytomed 6:495–501
Ze X, Duncan SH, Louis P, Flint HJ (2012) Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon. ISME J 6(8):1535–1543. https://doi.org/10.1038/ismej.2012.4
Zhang YH, Yoshida T, Isobe K, Rahman SMJ, Nagase F, Ding L, Nakashima I (1990) Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations. Immunology 70:405–410. https://doi.org/10.11501/3090919
Zorriehzahra MJ, Delshad ST, Adel M, Tiwari R, Karthik K, Dhama K, Lazado CC (2016) Probiotics as beneficial microbes in aquaculture: an update on their multiple modes of action: a review. Vet Q 36:228–241. https://doi.org/10.1080/01652176.2016.1172132
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Marcel Martínez-Porchas conceived the review, structured and wrote the document, organized the information collected by himself and the authors, and supervised the development of the writing. Rocío Valenzuela-Gutiérrez participated in the organization and writing of the manuscript and collected and analyzed information. Asunción Lago-Lestón collected and analyzed information about specific sections of the manuscript and supervised the development of the writing. Francisco Vargas-Albores collected and analyzed information about specific sections of the manuscript. Francesco Cicala collected and analyzed information about specific sections of the manuscript.
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Valenzuela-Gutiérrez, R., Lago-Lestón, A., Vargas-Albores, F. et al. Exploring the garlic (Allium sativum) properties for fish aquaculture. Fish Physiol Biochem 47, 1179–1198 (2021). https://doi.org/10.1007/s10695-021-00952-7
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DOI: https://doi.org/10.1007/s10695-021-00952-7