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MOF/Hip Fracture Ratio in a Belgian Cohort of Post-menopausal Women (FRISBEE): Potential Impact on the FRAX® Score

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Abstract

The ratio between major osteoporotic fractures (MOFs) and hip fractures in the Belgian FRAX® tool to predict fractures is currently based on Swedish data. We determined these ratios in a prospective cohort of Belgian postmenopausal women. 3560 women, aged 60–85 years (70.1 ± 6.4 years), were included in a prospective study from 2007 to 2013 and surveyed yearly (FRISBEE). We analyzed the number of validated incident fractures until October 2020 by age and sites and compared the MOFs/hip ratios in this cohort with those from the Swedish databases. We registered 1336 fractures (mean follow-up of 9.1 years). The MOFs/hip ratios extracted from the FRISBEE cohort were 10.7 [95% CI: (5.6–20.5)], 6.4 [4.7–8.7], and 5.0 [3.9–6.5] for women of 60–69, 70–79, and 80–89 years old, respectively. These ratios were 1.7–1.8 times higher for all age groups than those from the Swedish data, which decreased from 6.5 (60–64 years group) down to 1.8 (85–89 age group). The overall MOFs/hip ratio in Frisbee was 6.0 [5.9–6.1], which was higher than any Swedish ratio between 65 and 85 years. Nevertheless, the decrease of the ratios with age paralleled that observed in Sweden. In this Brussels prospective cohort, MOFs/hip ratios were 1.7–1.8 times those observed in Sweden currently used for MOFs prediction in the Belgian FRAX® version. This discrepancy can greatly modify the estimation of the risk of MOFs, which is among the main criteria used to recommend a pharmacological treatment for osteoporosis in several countries.

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Acknowledgements

BJJ, BP, AM designed the study. AM wrote the first draft of the manuscript. AM, BJJ, BP, MS, FB revised subsequent versions of the manuscript. All authors read and approved the final version of the paper. AM accepts responsibility for the integrity of the data analyses. The FRISBEE study is supported by CHU Brugmann and IRIS-Recherche.

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Authors and Affiliations

  1. Department of Geriatrics, CHU Brugmann, Université Libre de Bruxelles, Place van Gehuchten 4 Laeken, 1020, Brussels, Belgium

    A. Mugisha, M. Surquin & F. Benoit

  2. Department of Nuclear Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium

    P. Bergmann & V. Kinnard

  3. Laboratory of Translational Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium

    P. Bergmann & J. J. Body

  4. Department of Endocrinology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium

    L. Iconaru, F. Baleanu & J. J. Body

  5. Department of Internal Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium

    A. Charles, M. Surquin & J. J. Body

  6. Department of Gynaecology-Obstetrics, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium

    S. Rozenberg

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  1. A. Mugisha
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  2. P. Bergmann
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  4. L. Iconaru
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  6. A. Charles
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  8. S. Rozenberg
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  9. F. Benoit
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  10. J. J. Body
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Correspondence to A. Mugisha.

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Conflict of interest

A. Mugisha1, P. Bergmann, V. Kinnard, L. Iconar, F. Baleanu, Charles, M. Surquin, S. Rozenberg, F. Benoit, and J. J. Body authors state that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

All procedures were approved by CHU- Brugmann Hospital ethical committee et participant consent was obtained before study initiation (approval number B07720072493).

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Mugisha, A., Bergmann, P., Kinnard, V. et al. MOF/Hip Fracture Ratio in a Belgian Cohort of Post-menopausal Women (FRISBEE): Potential Impact on the FRAX® Score. Calcif Tissue Int 109, 600–604 (2021). https://doi.org/10.1007/s00223-021-00875-8

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  • DOI: https://doi.org/10.1007/s00223-021-00875-8

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