Horm Metab Res 2021; 53(06): 382-390
DOI: 10.1055/a-1463-3198
Endocrine Care

The Impact of Subclinical Hypothyroidism on Patients with Polycystic Ovary Syndrome: A Meta-Analysis

Yuling Xing
1   Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China
2   Graduate School of Hebei Medical University, Shijiazhuang, China
,
Jinhu Chen
1   Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China
,
Jing Liu
1   Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China
,
1   Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China
3   Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital Shijiazhuang, Hebei, China
4   Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China
› Author Affiliations

Abstract

The association between subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) has been shown in many studies. These findings are still controversial, however. It is unclear whether the co-incidence of subclinical hypothyroidism and polycystic ovary syndrome will affect the severity of metabolism. Therefore, we performed this meta-analysis to investigate the association. A comprehensive search strategy was developed to obtain all relevant studies published in PubMed, EMBASE, Cochrane Library, and Chinese Academic Journal Full-text Database (CNKI) up to 31 December 2020. We adopted the standardized mean difference (SMD) with 95% confidence intervals (CI) for evaluation, and sensitivity analysis was performed. Publication bias was analyzed and represented by a funnel plot, and funnel plot symmetry was assessed with Egger’s test. Twenty-seven studies with 4821 participants (1300 PCOS patients with SCH, 3521 PCOS patients without SCH) were included in the present meta-analysis,among which 71.31% chinese patients out of the total. The results showed that PCOS patients with SCH had higher levels of HOMA-IR, TG, TC, LDL, FBG, FCP, PRL and lower levels of HDL, LH and T. It also recognized the limitation of the lack of a consistent definition of hypothyroidism in the 27 studies included. The results of this study indicated that SCH may aggravate lipid and glucose metabolism in patients with PCOS.



Publication History

Received: 05 March 2021

Accepted after revision: 11 March 2021

Article published online:
21 June 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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