Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Metabolic Engineering

Modular biocatalysis for polyamines

Polyamines are a growing class of medically and agriculturally active biomolecules that have traditionally been difficult to source. Now, a bio-based platform for high-level production of diverse polyamines has been realized, showing the versatility of biocatalysis and the utility of conceptualizing metabolism as distinct modules.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Modular approach to produce diverse polyamines in yeast.

References

  1. Handa, A. K., Fatima, T. & Mattoo, A. K. Front. Chem. 6, 10 (2018).

    Article  Google Scholar 

  2. Qin, J. et al. Nat. Catal. https://doi.org/10.1038/s41929-021-00631-z (2021).

    Article  Google Scholar 

  3. Qin, J. et al. Nat. Commun. 6, 8224 (2015).

    Article  Google Scholar 

  4. Li, L. et al. ACS Sustain. Chem. Eng. 8, 2147–2157 (2020).

    Article  CAS  Google Scholar 

  5. Atsumi, S., Hanai, T. & Liao, J. C. Nature 451, 86–89 (2008).

    Article  CAS  Google Scholar 

  6. Ajikumar, P. K. et al. Science 330, 70–74 (2010).

    Article  CAS  Google Scholar 

  7. Li, Y. et al. Proc. Natl Acad. Sci. USA 115, E3922–E3931 (2018).

    Article  CAS  Google Scholar 

  8. Yang, J. E. et al. Nat. Commun. 9, 79 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hal S. Alper.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Reed, K.B., Alper, H.S. Modular biocatalysis for polyamines. Nat Catal 4, 449–450 (2021). https://doi.org/10.1038/s41929-021-00636-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41929-021-00636-8

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research