The design of an original molecular architecture featuring an unusual sterically congested C(sp2)–C(sp3) stereogenic axis with six high rotational barriers results in the formation of six stereoisomers. The configuration of this axis can be controlled by transition metal catalysis and one stereoisomer can be produced selectively.
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Bonne, D., Rodriguez, J. Selecting one out of six stereoisomers. Nat Catal 4, 451–452 (2021). https://doi.org/10.1038/s41929-021-00639-5
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DOI: https://doi.org/10.1038/s41929-021-00639-5