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The Predictive Value of Lp(a) for Adverse Cardiovascular Event in ACS Patients With an Achieved LDL-C Target at Follow Up After PCI

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Abstract

Low-density lipoprotein cholesterol (LDL-C) is a traditional and important risk factor for atherosclerotic cardiovascular disease (CVD). Recently, lipoprotein (a) (lp(a)) attracts considerable attention as a residual risk factor for CVD. However, the roles of lp(a) in acute coronary syndrome (ACS) patients with well-controlled LDL-C (≤1.8mmol/L) after percutaneous coronary intervention (PCI) remain unclear. Current study results demonstrated that occurrence of major adverse cardiovascular events (MACE) and recurrent myocardial infarction (MI) increased with the Lp(a) increasing in patients with LDL-C≤1.8mmol/L at 1-month follow-up. In relatively low-risk patients presented with ACS and underwent PCI (LDL-C ≤1.8mmol/L at 1-month follow-up), lp(a) is still independently related to adverse prognosis. Further researches of targeted therapy against lp(a) are warranted.

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Acknowledgements

The authors would like to thank Yidu Cloud Technology Co., Ltd for their assistance in data searching, extraction, and processing.

Funding

This study was funded by Liaoning Province Natural Science Foundation ((20180550892) to Dr. Yin and (2019-ZD-0635) to Dr. Ren).

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Author notes

  1. Yongkui Ren, Weili Pan, Yunlong Xia and Da Yin contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

    Yongkui Ren, Weili Pan, Xinsheng Li, Shuai Wang, Haichen Lv, Yao Yu, Minxian Wang, Yunlong Xia & Da Yin

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  1. Yongkui Ren
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  2. Weili Pan
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  3. Xinsheng Li
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  4. Shuai Wang
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  6. Yao Yu
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  7. Minxian Wang
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  8. Yunlong Xia
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  9. Da Yin
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Correspondence to Yunlong Xia or Da Yin.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Associate Editor Craig M. Stolen oversaw the review of this article

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Ren, Y., Pan, W., Li, X. et al. The Predictive Value of Lp(a) for Adverse Cardiovascular Event in ACS Patients With an Achieved LDL-C Target at Follow Up After PCI. J. of Cardiovasc. Trans. Res. 15, 67–74 (2022). https://doi.org/10.1007/s12265-021-10148-2

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  • DOI: https://doi.org/10.1007/s12265-021-10148-2

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