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VALVULAR DISEASE

Imperatives in mitral valve interventions: long-term survival, valve durability and valve performance

Nature Reviews Cardiology volume 18, pages 545–546 (2021)Cite this article

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Surgical mitral valve repair produces exceptional long-term survival, durable relief from mitral regurgitation, and physiological valve performance. Percutaneous mitral valve repair might prohibit subsequent surgical reconstruction. This finding has important implications, including for patient consent and clinical trial design. The objectives of mitral valve intervention must focus on life expectancy and long-term valve function.

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Fig. 1: Imperatives in mitral valve interventions.

References

  1. Feldman, T. et al. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST II. J. Am. Coll. Cardiol. 66, 2844–2854 (2015).

    Article  Google Scholar 

  2. Chikwe, J. et al. Mitral surgery after transcatheter edge-to-edge repair: Society of Thoracic Surgeons database analysis. J. Am. Coll. Cardiol. https://doi.org/10.1016/j.jacc.2021.04.062 (2021).

    Article  PubMed  Google Scholar 

  3. Ibrahim, M. E., Bavaria, J. E. & El-Hamamsy, I. A biological approach to aortic valve disease: durability and survival. Nat. Rev. Cardiol. 17, 754–756 (2020).

    Article  Google Scholar 

  4. Lazam, S. et al. Twenty-year outcome after mitral repair versus replacement for severe degenerative mitral regurgitation: analysis of a large, prospective, multicenter, international registry. Circulation 135, 410–422 (2017).

    Article  Google Scholar 

  5. Levine, R. A. et al. Mitral valve disease—morphology and mechanisms. Nat. Rev. Cardiol. 12, 689–710 (2015).

    Article  CAS  Google Scholar 

  6. Sonnenblick, E. H., Napolitano, L. M., Daggett, W. M. & Cooper, T. An intrinsic neuromuscular basis for mitral valve motion in the dog. Circ. Res. 21, 9–15 (1967).

    Article  CAS  Google Scholar 

  7. D’Agostino, R. S. et al. The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2019 update on outcomes and quality. Ann. Thorac. Surg. 107, 24–32 (2019).

    Article  Google Scholar 

  8. Otto, C. M. et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 143, e35–e71 (2021).

    PubMed  Google Scholar 

  9. De Bonis, M. et al. Long-term results (≤18 years) of the edge-to-edge mitral valve repair without annuloplasty in degenerative mitral regurgitation: implications for the percutaneous approach. Circulation 130, S19–S24 (2014).

    Article  Google Scholar 

  10. Chikwe, J. Ask the Expert Session: Management of degenerative mitral regurgitation in intermediate risk patients. Presented at the Society of Throacic Surgeons Annual Meeting 2021.

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Authors and Affiliations

  1. Division of Cardiovascular Surgery and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA

    Michael Ibrahim & W. Clark Hargrove III

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  1. Michael Ibrahim
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  2. W. Clark Hargrove III
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Correspondence to Michael Ibrahim.

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The authors declare no competing interests.

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Ibrahim, M., Hargrove, W.C. Imperatives in mitral valve interventions: long-term survival, valve durability and valve performance. Nat Rev Cardiol 18, 545–546 (2021). https://doi.org/10.1038/s41569-021-00590-9

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