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Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1

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Abstract

Ten compounds (1–10) were obtained from soil-derived Penicillium cremeogriseum W1-1 with the antimicrobial guided isolation procedure. Among them, 4 presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound 4 showed growth inhibition on drug-resistant pathogenic strains Escherichia coli and Candida albicans with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of C. albicans by eradicating biofilms. Interestingly, the fraction containing 4 presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.

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Acknowledgements

This work was supported financially by the National Natural Science Foundation of China (No. 81760632, 31660532, 81660582). The authors are grateful to introduced talents grand of Yunnan University (to Xiao-Dong Luo) and Yunnan Major Science and Technology Project (2019FY003004 and 2019ZF003) for financial support.

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Authors and Affiliations

  1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of EducationYunnan Research & Development Center for Natural ProductsSchool of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China

    Xu-Yan Sang, Zhao-Jie Wang, Ya-Bin Yang, Yong-Liang Wang, Mei-Ling Xiang, Dou-Ying Zhu, Ying Zhou, Xiao-Dong Luo & Li-Xing Zhao

  2. College of Life Science, Yunnan Institute of Microbiology, Yunnan University, 650091, Kunming, P. R. China

    Xu-Yan Sang, Yong-Liang Wang & Li-Xing Zhao

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  1. Xu-Yan Sang
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  2. Zhao-Jie Wang
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Correspondence to Xiao-Dong Luo or Li-Xing Zhao.

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Sang, XY., Wang, ZJ., Yang, YB. et al. Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1. Indian J Microbiol 61, 519–523 (2021). https://doi.org/10.1007/s12088-021-00957-z

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