Skip to main content

Advertisement

Log in

Debunking Myths: Sinus Headache

  • Headache (R.B. Halker Singh and J. VanderPluym, Section Editors)
  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Although sinus headache has been extensively reviewed and described, misdiagnosis remains common. This paper discusses the myths and truths about sinus headaches.

Recent Findings

Sinus headache is used colloquially to attribute facial pain to allergies or a sinus infection; however, most sinus headaches are migraine. Sinus-region pain from sinusitis and migraine share the same origins in the trigeminovascular system, but their causes are very different. After reviewing sinus anatomy and sinogenic pain, we provide information to assist clinicians in correctly diagnosing patients with the additional goal of avoiding unnecessary investigations and treatments. Migraine medications can be used as both a treatment and a diagnostic tool. Other differential diagnoses of facial pain are discussed.

Summary

Sinus headache is not a diagnosis. All patients with facial pain or pressure with sinus symptoms should be evaluated for migraine because most sinus headache presentations are migraine and require migraine-directed treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Abbreviations

ARS:

acute rhinosinusitis

CGRP:

calcitonin gene-related peptide

CRS:

chronic rhinosinusitis

CT:

computed tomography

ICHD:

International Classification of Headache Disorders

RS:

rhinosinusitis

SNOT-22:

22-item Sino-Nasal Outcome Test

TACs:

trigeminal autonomic cephalgias

References

  1. Centers for Disease Control and Prevention. National Ambulatory Medical Care Survey. National summary tables. 2016; https://www.cdc.gov/nchs/data/ahcd/namcs_summary/2016_namcs_web_tables.pdf. Accessed April 1, 2021.

  2. Cady RK, Dodick DW, Levine HL, Schreiber CP, Eross EJ, Setzen M, et al. Sinus headache: a neurology, otolaryngology, allergy, and primary care consensus on diagnosis and treatment. Mayo Clin Proc. 2005;80(7):908–16. https://doi.org/10.4065/80.7.908.

    Article  PubMed  Google Scholar 

  3. Lanza DC, Kennedy DW. Adult rhinosinusitis defined. Otolaryngol Head Neck Surg. 1997;117(3 Pt 2):S1–7. https://doi.org/10.1016/s0194-5998(97)70001-9.

    Article  CAS  PubMed  Google Scholar 

  4. Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl):S1–s39. https://doi.org/10.1177/0194599815572097.

    Article  PubMed  Google Scholar 

  5. Gray ST, Phillips KM, Hoehle LP, Caradonna DS, Sedaghat AR. The 22-item Sino-Nasal Outcome Test accurately reflects patient-reported control of chronic rhinosinusitis symptomatology. Int Forum Allergy Rhinol. 2017;7(10):945–51. https://doi.org/10.1002/alr.21992.

    Article  PubMed  Google Scholar 

  6. Farhood Z, Schlosser RJ, Pearse ME, Storck KA, Nguyen SA, Soler ZM. Twenty-two-item Sino-Nasal Outcome Test in a control population: a cross-sectional study and systematic review. Int Forum Allergy Rhinol. 2016;6(3):271–7. https://doi.org/10.1002/alr.21668.

    Article  PubMed  Google Scholar 

  7. Lal D, Rounds A, Dodick DW. Comprehensive management of patients presenting to the otolaryngologist for sinus pressure, pain, or headache. Laryngoscope. 2015;125(2):303–10. https://doi.org/10.1002/lary.24926.

    Article  PubMed  Google Scholar 

  8. (IHS) HCCotIHS. The international classification of headache disorders, 3rd edition. Cephalgia. 2018;38(1):1–211. https://doi.org/10.1177/0333102417738202.

    Article  Google Scholar 

  9. Lipton RB, Dodick D, Sadovsky R, Kolodner K, Endicott J, Hettiarachchi J, et al. A self-administered screener for migraine in primary care: the ID Migraine validation study. Neurology. 2003;61(3):375–82. https://doi.org/10.1212/01.wnl.0000078940.53438.83.

    Article  CAS  PubMed  Google Scholar 

  10. Dodick DW. Pearls: headache. Semin Neurol. 2010;30(1):74–81. https://doi.org/10.1055/s-0029-1245000.

    Article  PubMed  Google Scholar 

  11. Cousins G, Hijazze S, Van de Laar FA, Fahey T. Diagnostic accuracy of the ID Migraine: a systematic review and meta-analysis. Headache. 2011;51(7):1140–8. https://doi.org/10.1111/j.1526-4610.2011.01916.x.

    Article  PubMed  Google Scholar 

  12. Rocha-Filho PA, Marques KS, Torres RC, Leal KN. Osmophobia and headaches in primary care: prevalence, associated factors, and importance in diagnosing migraine. Headache. 2015;55(6):840–5. https://doi.org/10.1111/head.12577.

    Article  PubMed  Google Scholar 

  13. von Eckardstein KL, Keil M, Rohde V. Unnecessary dental procedures as a consequence of trigeminal neuralgia. Neurosurg Rev. 2015;38(2):355–60; discussion 60. https://doi.org/10.1007/s10143-014-0591-1.

    Article  Google Scholar 

  14. Simms HN, Honey CR. The importance of autonomic symptoms in trigeminal neuralgia. Clinical article J Neurosurg. 2011;115(2):210–6. https://doi.org/10.3171/2011.4.Jns101843.

    Article  PubMed  Google Scholar 

  15. Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. Trigeminal neuralgia: diagnosis and treatment. Cephalalgia. 2017;37(7):648–57. https://doi.org/10.1177/0333102416687280.

    Article  PubMed  Google Scholar 

  16. Lew D, Southwick FS, Montgomery WW, Weber AL, Baker AS. Sphenoid sinusitis. A review of 30 cases. N Engl J Med. 1983;309(19):1149–54. https://doi.org/10.1056/nejm198311103091904.

    Article  CAS  PubMed  Google Scholar 

  17. Turgut S, Ozcan KM, Celikkanat S, Ozdem C. Isolated sphenoid sinusitis. Rhinology. 1997;35(3):132–5.

    CAS  PubMed  Google Scholar 

  18. Fadda G-L, D'Eramo A, Grosso A, Galizia A, Cavallo G. Isolated sphenoid sinus inflammatory disease—a report of 14 cases. Iranian journal of otorhinolaryngology. 2020;32(109):101–7. https://doi.org/10.22038/ijorl.2019.39416.2304.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Goldman GE, Fontanarosa PB, Anderson JM. Isolated sphenoid sinusitis. Am J Emerg Med. 1993;11(3):235–8. https://doi.org/10.1016/0735-6757(93)90133-v.

    Article  CAS  PubMed  Google Scholar 

  20. Fooanant S, Angkurawaranon S, Angkurawaranon C, Roongrotwattanasiri K, Chaiyasate S. Sphenoid sinus diseases: a review of 1,442 patients. International Journal of Otolaryngology. 2017;2017:9650910–7. https://doi.org/10.1155/2017/9650910.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Goldman A. Complications of sphenoid sinusitis. Oper Tech Otolayngol Head Neck Surg. 2003;14(3):216–8. https://doi.org/10.1016/S1043-1810(03)90029-7.

    Article  Google Scholar 

  22. La Mantia I, Grillo C, Andaloro C. Rhinogenic contact point headache: surgical treatment versus medical treatment. J Craniofac Surg. 2018;29(3):e228–e30. https://doi.org/10.1097/scs.0000000000004211.

    Article  PubMed  Google Scholar 

  23. Behin F, Behin B, Bigal ME, Lipton RB. Surgical treatment of patients with refractory migraine headaches and intranasal contact points. Cephalalgia. 2005;25(6):439–43. https://doi.org/10.1111/j.1468-2982.2004.00877.x.

    Article  CAS  PubMed  Google Scholar 

  24. Abu-Bakra M, Jones NS. Prevalence of nasal mucosal contact points in patients with facial pain compared with patients without facial pain. J Laryngol Otol. 2001;115(8):629–32. https://doi.org/10.1258/0022215011908685.

    Article  CAS  PubMed  Google Scholar 

  25. Tange RA. Some historical aspects of the surgical treatment of the infected maxillary sinus. Rhinology. 1991;29(2):155–62.

    CAS  PubMed  Google Scholar 

  26. Formby ML. The maxillary sinus. Proceedings of the Royal Society of Medicine. 1960;53(3):163–8.

    Article  CAS  Google Scholar 

  27. Lafci Fahrioglu S, VanKampen N, Andaloro C. Anatomy, head and neck, sinus function and development. Treasure Island, FL: StatPearls Publishing; 2020.

  28. Cavalcanti MC, Guirado TE, Sapata VM, Costa C, Pannuti CM, Jung RE, et al. Maxillary sinus floor pneumatization and alveolar ridge resorption after tooth loss: a cross-sectional study. Braz Oral Res. 2018;32:e64. https://doi.org/10.1590/1807-3107BOR-2018.vol32.0064.

    Article  PubMed  Google Scholar 

  29. Henson B, Drake T, Edens M. Anatomy, head and neck, nose sinuses. Treasure Island, FL: StatPearls Publishing; 2020.

  30. Pooshpas P, Nookala V. Anatomy, head and neck, optic canal. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. 2020.

  31. Bahşi I, Orhan M, Kervancıoğlu P, Yalçın ED. Morphometric evaluation and surgical implications of the infraorbital groove, canal and foramen on cone-beam computed tomography and a review of literature. Folia Morphol (Warsz). 2019;78(2):331–43. https://doi.org/10.5603/FM.a2018.0084.

    Article  Google Scholar 

  32. Mayberg M, Langer RS, Zervas NT, Moskowitz MA. Perivascular meningeal projections from cat trigeminal ganglia: possible pathway for vascular headaches in man. Science. 1981;213(4504):228–30. https://doi.org/10.1126/science.6166046.

    Article  CAS  PubMed  Google Scholar 

  33. Tajti J, Szok D, Majláth Z, Tuka B, Csáti A, Vécsei L. Migraine and neuropeptides. Neuropeptides. 2015;52:19–30. https://doi.org/10.1016/j.npep.2015.03.006.

    Article  CAS  PubMed  Google Scholar 

  34. Tolba R, Weiss AL, Denis DJ. Sphenopalatine ganglion block and radiofrequency ablation: technical notes and efficacy. Ochsner J. 2019;19(1):32–7. https://doi.org/10.31486/toj.18.0163.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Arslan HH, Tokgöz E, Yildizoğlu Ü, Durmaz A, Bek S, Gerek M. Evaluation of the changes in the nasal cavity during the migraine attack. J Craniofac Surg. 2014;25(5):e446–e9. https://doi.org/10.1097/SCS.0b013e31827c80b1.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Barbanti P, Fabbrini G, Pesare M, Vanacore N, Cerbo R. Unilateral cranial autonomic symptoms in migraine. Cephalalgia. 2002;22(4):256–9. https://doi.org/10.1046/j.1468-2982.2002.00358.x.

    Article  CAS  PubMed  Google Scholar 

  37. Obermann M, Yoon MS, Dommes P, Kuznetsova J, Maschke M, Weimar C, et al. Prevalence of trigeminal autonomic symptoms in migraine: a population-based study. Cephalalgia. 2007;27(6):504–9. https://doi.org/10.1111/j.1468-2982.2007.01316.x.

    Article  CAS  PubMed  Google Scholar 

  38. Gupta R, Bhatia MS. A report of cranial autonomic symptoms in migraineurs. Cephalalgia. 2007;27(1):22–8. https://doi.org/10.1111/j.1468-2982.2006.01237.x.

    Article  CAS  PubMed  Google Scholar 

  39. Haytoglu Z, Herguner MO. Cranial autonomic symptoms, neck pain: challenges in pediatric migraine. Ann Indian Acad Neurol. 2019;22(3):282–5. https://doi.org/10.4103/aian.AIAN_206_18.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Yoon MS, Mueller D, Hansen N, Poitz F, Slomke M, Dommes P, et al. Prevalence of facial pain in migraine: a population-based study. Cephalalgia. 2010;30(1):92–6. https://doi.org/10.1111/j.1468-2982.2009.01899.x.

    Article  PubMed  Google Scholar 

  41. Eross E, Dodick D, Eross M. The sinus, allergy and migraine study (SAMS). Headache. 2007;47(2):213–24. https://doi.org/10.1111/j.1526-4610.2006.00688.x.

    Article  PubMed  Google Scholar 

  42. Cady RK, Schreiber CP. Sinus problems as a cause of headache refractoriness and migraine chronification. Curr Pain Headache Rep. 2009;13(4):319–25. https://doi.org/10.1007/s11916-009-0051-8.

    Article  PubMed  Google Scholar 

  43. Chapurin N, Pynnonen MA, Roberts R, Schulz K, Shin JJ, Witsell DL, et al. CHEER national study of chronic rhinosinusitis practice patterns: disease comorbidities and factors associated with surgery. Otolaryngol Head Neck Surg. 2017;156(4):751–6. https://doi.org/10.1177/0194599817691476.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Al-Hashel JY, Ahmed SF, Alroughani R, Goadsby PJ. Migraine misdiagnosis as a sinusitis, a delay that can last for many years. J Headache Pain. 2013;14:97. https://doi.org/10.1186/1129-2377-14-97.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Cady RK, Schreiber CP. Sinus headache: a clinical conundrum. Otolaryngol Clin N Am. 2004;37(2):267–88. https://doi.org/10.1016/s0030-6665(03)00181-6.

    Article  Google Scholar 

  46. Jayawardena ADL, Chandra R. Headaches and facial pain in rhinology. Am J Rhinol Allergy. 2018;32(1):12–5. https://doi.org/10.2500/ajra.2018.32.4501.

    Article  PubMed  Google Scholar 

  47. Nikkerdar N, Eivazi N, Lotfi M, Golshah A. Agreement between cone-beam computed tomography and functional endoscopic sinus surgery for detection of pathologies and anatomical variations of the paranasal sinuses in chronic rhinosinusitis patients: a prospective study. Imaging science in dentistry. 2020;50(4):299–307. https://doi.org/10.5624/isd.2020.50.4.299.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Bhattacharyya N, Lee LN. Evaluating the diagnosis of chronic rhinosinusitis based on clinical guidelines and endoscopy. Otolaryngol Head Neck Surg. 2010;143(1):147–51. https://doi.org/10.1016/j.otohns.2010.04.012.

    Article  PubMed  Google Scholar 

  49. Mehle ME, Kremer PS. Sinus CT scan findings in “sinus headache” migraineurs. Headache. 2008;48(1):67–71. https://doi.org/10.1111/j.1526-4610.2007.00811.x.

    Article  PubMed  Google Scholar 

  50. Wuister AM, Goto NA, Oostveen EJ, de Jong WU, van der Valk ES, Kaper NM, et al. Nasal endoscopy is recommended for diagnosing adults with chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2014;150(3):359–64. https://doi.org/10.1177/0194599813514510.

    Article  PubMed  Google Scholar 

  51. Lohiya SS, Patel SV, Pawde AM, Bokare BD, Sakhare PT. Comparative study of diagnostic nasal endoscopy and CT paranasal sinuses in diagnosing chronic rhinosinusitis. Indian J Otolaryngol Head Neck Surg. 2016;68(2):224–9. https://doi.org/10.1007/s12070-015-0907-7.

    Article  PubMed  Google Scholar 

  52. Dodick DW, Loder EW, Manack Adams A, Buse DC, Fanning KM, Reed ML, et al. Assessing barriers to chronic migraine consultation, diagnosis, and treatment: results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) study. Headache. 2016;56(5):821–34. https://doi.org/10.1111/head.12774.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Lemiengre MB, van Driel ML, Merenstein D, Young J, De Sutter AI. Antibiotics for clinically diagnosed acute rhinosinusitis in adults. Cochrane. Database Syst Rev. 2012;10:Cd006089. https://doi.org/10.1002/14651858.CD006089.pub4.

    Article  Google Scholar 

  54. Kari E, DelGaudio JM. Treatment of sinus headache as migraine: the diagnostic utility of triptans. Laryngoscope. 2008;118(12):2235–9. https://doi.org/10.1097/MLG.0b013e318182f81d.

    Article  CAS  PubMed  Google Scholar 

  55. Levine HL, Setzen M, Cady RK, Dodick DW, Schreiber CP, Eross EJ, et al. An otolaryngology, neurology, allergy, and primary care consensus on diagnosis and treatment of sinus headache. Otolaryngol Head Neck Surg. 2006;134(3):516–23. https://doi.org/10.1016/j.otohns.2005.11.024.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank the staff of Neuroscience Publications at Barrow Neurological Institute for assistance with manuscript preparation.

Author information

Authors and Affiliations

Authors

Contributions

Robblee and Secora both performed the literature search and wrote the manuscript.

Corresponding author

Correspondence to Jennifer Robblee.

Ethics declarations

Ethics Approval

Not applicable.

Conflict of Interest

Dr. Robblee and Ms. Secora have nothing to disclose.

Informed Consent

Not applicable.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Headache

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Robblee, J., Secora, K.A. Debunking Myths: Sinus Headache. Curr Neurol Neurosci Rep 21, 42 (2021). https://doi.org/10.1007/s11910-021-01127-w

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11910-021-01127-w

Keywords

Navigation