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Analysis of a two-dimensional triply haptotactic model with a fusogenic oncolytic virus and syncytia

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Abstract

In this paper, we concerned with a haptotaxis system proposed as a model for fusogenic oncolytic virotherapy and syncytia, accounting for interaction between uninfected cancer cells, infected cancer cells, syncytia cancer cells, extracellular matrix and oncolytic virus. We present the global classical solution in two-dimensional bounded domains under appropriate regularity assumptions on the initial data.

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Acknowledgements

Guoqiang Ren is supported by NSF of China (Grant No 12001214). Jinlong Wei is supported by NSF of China (Grant Nos 11501577 and 61773401).

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Authors and Affiliations

  1. School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

    Guoqiang Ren

  2. Hubei Key Laboratory of Engineering Modeling and Scientific Computing, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

    Guoqiang Ren

  3. School of Statistics and Mathematics, Zhongnan University of Economics and Law, Wuhan, 430073, People’s Republic of China

    Jinlong Wei

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  1. Guoqiang Ren
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Correspondence to Jinlong Wei.

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Ren, G., Wei, J. Analysis of a two-dimensional triply haptotactic model with a fusogenic oncolytic virus and syncytia. Z. Angew. Math. Phys. 72, 134 (2021). https://doi.org/10.1007/s00033-021-01572-0

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  • DOI: https://doi.org/10.1007/s00033-021-01572-0

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