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Synthesis and antibacterial activity of novel Schiff bases of thiosemicarbazone derivatives with adamantane moiety

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Abstract

Increased bacterial resistance to antibiotics is a major threat to human health, and it is particularly important to develop novel antibiotic drugs. Here, we designed a series of Schiff base thiosemicarbazone derivatives containing an adamantane moiety, and carried out the structural characterization of the compounds and in vitro antibacterial activity tests. Compound 7e was as effective as the commonly used antibiotic ampicillin against the Gram-negative bacterium Escherichia coli, and compound 7g had a good inhibitory effect against Gram-positive Bacillus subtilis. These findings provide data for the development of better thiosemicarbazone antibacterial agents.

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Acknowledgements

We thank Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

Funding

This work was financially supported by the National Natural Science Foundation of China (21502008) and Natural Science Foundation of Jilin Province (00005005031).

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Authors and Affiliations

  1. College of Chemistry and Life Science, Changchun University of Technology, 130012, Changchun, China

    Jiahui Zhu, Guosheng Teng, Dongfeng Li, Ruibin Hou & Yan Xia

  2. Advanced Institute of Materials Science, Changchun University of Technology, 130012, Changchun, China

    Jiahui Zhu, Ruibin Hou & Yan Xia

Authors
  1. Jiahui Zhu
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  2. Guosheng Teng
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  3. Dongfeng Li
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  4. Ruibin Hou
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  5. Yan Xia
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Contributions

JZ and YX performed all experiments, purified all compounds, analyzed the data and summarized the results. JZ tested all compounds for their antibacterial activity. DL and GT helped in compiling the data of the manuscript. YX and RH conceived and designed this research and wrote the manuscript. All authors have contributed to the final version and approved the final manuscript.

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Correspondence to Ruibin Hou or Yan Xia.

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Zhu, J., Teng, G., Li, D. et al. Synthesis and antibacterial activity of novel Schiff bases of thiosemicarbazone derivatives with adamantane moiety. Med Chem Res 30, 1534–1540 (2021). https://doi.org/10.1007/s00044-021-02759-w

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  • DOI: https://doi.org/10.1007/s00044-021-02759-w

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