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Cellular communication network factor 3 in cartilage development and maintenance

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Cellular communication network factor (CCN) 3 is one of the classical members of the CCN family, which are characterized by common molecular structures and multiple functionalities. Although this protein was discovered as a gene product overexpressed in a truncated form in nephroblastoma, recent studies have revealed its physiological roles in the development and homeostasis of mammalian species, in addition to its pathological association with a number of diseases. Cartilage is a tissue that creates most of the bony parts and cartilaginous tissues that constitute the human skeleton, in which CCN3 is also differentially produced to exert its molecular missions therein. In this review article, after the summary of the molecular structure and function of CCN3, recent findings on the regulation of ccn3 expression and the roles of CCN3 in endochondral ossification, cartilage development, maintenance and disorders are introduced with an emphasis on the metabolic regulation and function of this matricellular multifunctional molecule.

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Acknowledgements

The authors would like to thank Ms. Yoshiko Miyake for her secretarial assistance. This study was supported by JSPS KAKENHI Grant Numbers JP19K22716, JP19K10109 and JP20K09889.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan

    Satoshi Kubota, Kazumi Kawata, Takako Hattori & Takashi Nishida

  2. Department of Oral Biochemistry, Asahi University School of Dentistry, Mizuho, Japan

    Harumi Kawaki

  3. International CCN Society, Marseille, France

    Bernard Perbal

  4. Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, Okayama, Japan

    Takashi Nishida

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  1. Satoshi Kubota
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  2. Harumi Kawaki
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  3. Bernard Perbal
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  4. Kazumi Kawata
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  5. Takako Hattori
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Correspondence to Satoshi Kubota.

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Kubota, S., Kawaki, H., Perbal, B. et al. Cellular communication network factor 3 in cartilage development and maintenance. J. Cell Commun. Signal. 15, 533–543 (2021). https://doi.org/10.1007/s12079-021-00629-z

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