Potential role of mobile rapid on-site evaluation® in thyroid fine-needle aspiration cytology to reduce delayed repeated aspiration

Toshitetsu Hayashi; Noriko Akiyama; Risa Kanematsu; Miyoko Higuchi; Ayana Suzuki; Aki Tanaka; Naoki Yamao; Seiji Kuma; Mitsuyoshi Hirokawa; Akira Miyauchi

doi:10.1507/endocrj.EJ21-0010

RAPID COMMUNICATION

Potential role of mobile rapid on-site evaluation^® in thyroid fine-needle aspiration cytology to reduce delayed repeated aspiration

Toshitetsu Hayashi, Noriko Akiyama, Risa Kanematsu, Miyoko Higuchi, Ayana Suzuki, Aki Tanaka, Naoki Yamao, Seiji Kuma, Mitsuyoshi Hirokawa, Akira Miyauchi

Author information

Toshitetsu Hayashi
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Noriko Akiyama
Cytology Department, Osaka Cytopathology Laboratories Co., Ltd, Osaka 533-0024, Japan
Yamachu Co., Ltd, Medical Equipment Research and Development Corporation, Chiba 292-0838, Japan
Risa Kanematsu
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Miyoko Higuchi
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Ayana Suzuki
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Aki Tanaka
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Naoki Yamao
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Seiji Kuma
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Mitsuyoshi Hirokawa
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
Akira Miyauchi
Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan

Keywords: Mobile rapid on-site evaluation, Fine needle aspiration cytology, Thyroid, Adequacy, Delayed repeated aspiration

JOURNAL FREE ACCESS FULL-TEXT HTML

2021 Volume 68 Issue 7 Pages 865-870

DOI https://doi.org/10.1507/endocrj.EJ21-0010

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Abstract

Rapid on-site evaluation of fine-needle aspiration cytology is time-consuming and requires specialized cytopathology staff. Mobile Rose^® is a newly developed device for rapid on-site evaluation of fine-needle aspiration cytology. This study aimed to investigate the potential role of Mobile Rose^® in reducing delayed repeated aspiration of the thyroid. A total of 120 cytological samples were collected and observed using Mobile Rose^® after fine-needle aspiration cytology between September and October 2020, with immediate assessment of minimal or no cell clusters after conventional smear preparation. After qualifying and scoring, needle washout materials were prepared using the BD CytoRich^TM method and correlated with cytology results. The average turn-around time of Mobile Rose^® was found to be 1.5 minutes. Sensitivity, specificity, positive predictive value, and negative predictive value were 94.4%, 100%, 100%, and 57.1%, respectively. False-negative results were attributed to small aggregates of cells that were difficult to distinguish from the background and artifacts. Mobile Rose^® may represent an important innovation for rapid on-site evaluation that is fast, has high diagnostic performance, does not require the presence of specialized cytology staff, and can reduce delayed repeated aspiration of the thyroid gland. However, further minor improvements and confirmation are required.

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