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Changes in High-Frequency Intracardiac Electrogram Indicate Cardiac Ischemia

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Abstract

High-frequency QRS (HFQRS) analysis of surface ECG is a reliable marker of cardiac ischemia (CI). This study aimed to assess the response of HFQRS signals from standard intracardiac electrodes (iHFQRS) to CI in swine and compare them with conventional ST-segment deviations. Devices with three intracardiac leads were implanted in three swine in a controlled environment. CI was induced by inflating a balloon in epicardial coronary arteries. A designated signal-processing algorithm was applied to quantify the iHFQRS content before, during, and after each occlusion. iHFQRS time responses were compared to conventional ST-segment deviations. Thirty-three over thirty-nine (85%) of the occlusions presented significant reduction in the iHFQRS signal, preceding ST-segment change, being the only indicator of CI in brief occlusions. iHFQRS was found to be an early indicator for the onset of CI and demonstrated superior sensitivity to conventional ST-segment deviations during brief ischemic episodes.

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Acknowledgements

All animal procedures were approved by the national ethical committee and performed in strict compliance with institutional and national guidelines for the care and use of laboratory animals (permit number IL-17-8-298).

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Authors and Affiliations

  1. The Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel

    Noam Omer & Shimon Abboud

  2. BSP Medical Ltd., Tel Aviv, Israel

    Elad Bergman, Tamir Ben-David, Shimmy Huri, Amir Beker & Yair Granot

  3. Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel

    David Meerkin

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  1. Noam Omer
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  2. Elad Bergman
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Correspondence to Noam Omer.

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Associate Editor Marat Fudim oversaw the review of this article

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Omer, N., Bergman, E., Ben-David, T. et al. Changes in High-Frequency Intracardiac Electrogram Indicate Cardiac Ischemia. J. of Cardiovasc. Trans. Res. 15, 84–94 (2022). https://doi.org/10.1007/s12265-021-10146-4

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  • DOI: https://doi.org/10.1007/s12265-021-10146-4

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