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Lysophosphatidic Acid Regulates Rho Family of GTPases in Lungs

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Abstract

The bio-active lipid, lysophosphatidic acid (LPA) interacts with various lysophosphatidic acid receptors (LPARs) to affect a variety of cellular functions, including proliferation, differentiation, survival, migration, morphogenesis and others. The Rho family of small GTPases, is well-known downstream signaling pathways activated by LPA. Among the Rho GTPases, RhoA, Rac1, and Cdc42 are best characterized and LPA-induced activation of the GTPases RhoA, Rac1, and Cdc42 influences a wide range of cellular processes and functions such as cell differentiation, contractile movements, cellular migration, or infiltration. In this review, we will briefly discuss the interplay between LPA and each of these three Rho family proteins, summarizing the main interactions between them. Our discussion will focus mainly on their interplay within lung endothelial and epithelial cells, drawing attention to how these interactions may contribute to pro-inflammatory processes.

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Acknowledgements

This work was supported by grants from National Institutes of Health (R01 GM115389, R01HL151513 to J.Z.).

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Authors and Affiliations

  1. Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA

    Kevin C. Tran & Jing Zhao

  2. Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA

    Jing Zhao

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  1. Kevin C. Tran
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  2. Jing Zhao
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Correspondence to Jing Zhao.

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Tran, K.C., Zhao, J. Lysophosphatidic Acid Regulates Rho Family of GTPases in Lungs. Cell Biochem Biophys 79, 493–496 (2021). https://doi.org/10.1007/s12013-021-00993-y

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  • DOI: https://doi.org/10.1007/s12013-021-00993-y

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