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Efficient Synthesis of 3-(Arenesulfinyl)indoles in Water

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Abstract

The first example of the sulfinylation of indoles with arylsulfinamides in water in the presence of trifluoroacetic acid as a promoter is described. The reaction occurs smoothly at room temperature under environmentally benign conditions without any catalyst, additive, ligand, or organic solvent. The developed sulfoxide synthetic protocol is attractive due to the use of water as the solvent and provides a novel and efficient route to a wide range of functionalized diaryl sulfoxides.

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Funding

This research was funded by the National Natural Science Foundation of China (project nos. 21672046 and 21372054), Fundamental Research Funds for the Central Universities (project no. HIT.NSRIF.201708), and Foundation from the Huancui District of the Wehai City.

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Authors and Affiliations

  1. School of Marine Science and Technology, Weihai Marine Organism and Medical Technology Research Institute, Harb in Institute of Technology, 264209, Weihai, China

    Y. Liu, Z. Y. Zhang, Y. Z. Ji, H. J. Li & Y. C. Wu

  2. Weihai Huiankang Biotechnology Co., Ltd, 264200, Weihai, China

    H. J. Li

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  1. Y. Liu
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  2. Z. Y. Zhang
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  3. Y. Z. Ji
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  4. H. J. Li
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Correspondence to Y. Liu or Y. C. Wu.

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Liu, Y., Zhang, Z.Y., Ji, Y.Z. et al. Efficient Synthesis of 3-(Arenesulfinyl)indoles in Water. Russ J Org Chem 57, 831–841 (2021). https://doi.org/10.1134/S1070428021050109

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  • DOI: https://doi.org/10.1134/S1070428021050109

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