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Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG

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Abstract

Animal and clinical studies have revealed that (–)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo. Moreover, glucosyl-hesperidin intake potentiated the green tea-elicited upregulation of the anti-inflammatory factor, toll-interacting protein.

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Fig. 1
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Abbreviations

cGMP:

Cyclic guanosine monophosphate

EGCG:

(–)-Epigallocatechin-3-O-gallate

Tollip:

Toll-interacting protein

TLR:

Toll-like receptor

PDE5:

Phosphodiesterase 5

67LR:

67-KDa laminin receptor

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Acknowledgements

This is work was supported in part by JSPS KAKENHI Grant, JP15H02448 and JP20H05683 to H. Tachibana, JP20K05960 to M. Kumazoe.

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Author notes

  1. Motofumi Kumazoe and Yasutake Tanaka contributed equally to this work.

Authors and Affiliations

  1. Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan

    Motofumi Kumazoe, Yasutake Tanaka, Ren Yoshitomi, Yuki Marugame, Kwan-Woo Lee, Hiroaki Onda, Yoshinori Fujimura & Hirofumi Tachibana

  2. Agriculture and Biotechnology Business Division, Toyota Motor Corporation, Aichi, 470-8571, Japan

    Madoka Yonekura & Yasuyo Shimamoto

Authors
  1. Motofumi Kumazoe
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  2. Yasutake Tanaka
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  3. Ren Yoshitomi
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  10. Hirofumi Tachibana
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Correspondence to Hirofumi Tachibana.

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Kumazoe, M., Tanaka, Y., Yoshitomi, R. et al. Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG. J Nat Med 75, 1037–1042 (2021). https://doi.org/10.1007/s11418-021-01538-6

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