Abstract
Purpose of Review
Post-traumatic headache is a common disorder in the pediatric age group, seen both by child neurologists and by non-neurologists. The current review of post-traumatic headache in children and adolescents aims to review the pathophysiology, risk factors, clinical features, neuroimaging, and both acute and preventive treatment options.
Recent Findings
Recent literature provides insight into specific risk factors in the pediatric age group for developing post-traumatic headache as well as unique pathophysiologic changes seen in neuroimaging and neurometabolic pathways. It also elucidates common treatment options and novel treatments being currently explored, such as with monoclonal antibodies to CGRP. Finally, current evidence and guidelines recommend the benefit of a gradual return to normal activity based on symptom stability rather than a specific time period.
Summary
Review of literature on pediatric post-traumatic headache reveals a growing understanding of the factors involved in developing headache after head trauma and the diagnosis/treatment of headache though future research will help further elucidate these areas.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Post-Traumatic Headache American Migraine Foundation webpage 2016 Available from: https://americanmigrainefoundation.org/resource-library/post-traumatic-headache/.
Tessler J, Horn LJ. Post-Traumatic Headache. StatPearls. Treasure Island (FL): StatPearls Publishing. Copyright © 2021, StatPearls Publishing LLC.
Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211.
Ashina H, Porreca F, Anderson T, Amin FM, Ashina M, Schytz HW, et al. Post-traumatic headache: epidemiology and pathophysiological insights. Nat Rev Neurol. 2019;15(10):607–17 Study of epidemiology of post-traumatic headache.
Schwedt TJ, Chong CD, Peplinski J, Ross K, Berisha V. Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure. J Headache Pain. 2017;18(1):87.
Obermann M, Nebel K, Schumann C, Holle D, Gizewski ER, Maschke M, et al. Gray matter changes related to chronic posttraumatic headache. Neurology. 2009;73(12):978–83.
Chong CD, Berisha V, Chiang CC, Ross K, Schwedt TJ. Less Cortical Thickness in Patients With Persistent Post-Traumatic Headache Compared With Healthy Controls: An MRI Study. Headache. 2018;58(1):53–61.
Meyer EJ, Stout JN, Chung AW, Grant PE, Mannix R, Gagoski B. Longitudinal Changes in Magnetic Resonance Spectroscopy in Pediatric Concussion: A Pilot Study. Front Neurol. 2019;10:556 Study of MRI changes in Pediatric Concussion.
Bartnik-Olson BL, Holshouser B, Wang H, Grube M, Tong K, Wong V, et al. Impaired neurovascular unit function contributes to persistent symptoms after concussion: a pilot study. J Neurotrauma. 2014;31(17):1497–506.
Sarmento E, Moreira P, Brito C, Souza J, Jevoux C, Bigal M. Proton spectroscopy in patients with post-traumatic headache attributed to mild head injury. Headache. 2009;49(9):1345–52.
Maugans TA, Farley C, Altaye M, Leach J, Cecil KM. Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics. 2012;129(1):28–37.
Bree D, Levy D. Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache. Cephalalgia. 2018;38(2):246–58.
Ashina H, Iljazi A, Al-Khazali HM, Eigenbrodt AK, Larsen EL, Andersen AM, et al. Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study. J Headache Pain. 2020;21(1):62.
Blume HK, Vavilala MS, Jaffe KM, Koepsell TD, Wang J, Temkin N, et al. Headache after pediatric traumatic brain injury: a cohort study. Pediatrics. 2012;129(1):e31–9.
Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, et al. Predictors of clinical recovery from concussion: a systematic review. Br J Sports Med. 2017;51(12):941–8.
McConnell B, Duffield T, Hall T, Piantino J, Seitz D, Soden D, et al. Post-traumatic Headache After Pediatric Traumatic Brain Injury: Prevalence, Risk Factors, and Association With Neurocognitive Outcomes, J Child Neurol. 2020;35(1):63–70 An important study of factors associated with headache following pediatric traumatic brain injury.
Kuczynski A, Crawford S, Bodell L, Dewey D, Barlow KM. Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Dev Med Child Neurol. 2013;55(7):636–41.
Shaw L, Morozova M, Abu-Arafeh I. Chronic post-traumatic headache in children and adolescents: systematic review of prevalence and headache features. Pain Manag. 2018;8(1):57–64.
Babcock L, Byczkowski T, Wade SL, Ho M, Mookerjee S, Bazarian JJ. Predicting postconcussion syndrome after mild traumatic brain injury in children and adolescents who present to the emergency department. JAMA Pediatr. 2013;167(2):156–61.
Luther M, Poppert Cordts KM, Williams CN. Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery. Sleep. 2020;43(10).
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, et al. Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list. Neurology. 2019;92(3):134–44.
Kacperski J, Arthur T. Management of post-traumatic headaches in children and adolescents. Headache. 2016;56(1):36–48.
Babl FE, Borland ML, Phillips N, Kochar A, Dalton S, McCaskill M, et al. Accuracy of PECARN, CATCH, and CHALICE head injury decision rules in children: a prospective cohort study. Lancet. 2017;389(10087):2393–402.
Kuppermann N, Holmes JF, Dayan PS, Hoyle JD Jr, Atabaki SM, Holubkov R, et al. Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet. 2009;374(9696):1160–70.
Lorton F, Poullaouec C, Legallais E, Simon-Pimmel J, Chêne MA, Leroy H, et al. Validation of the PECARN clinical decision rule for children with minor head trauma: a French multicenter prospective study. Scand J Trauma Resusc Emerg Med. 2016;24:98.
Osmond MH, Klassen TP, Wells GA, Correll R, Jarvis A, Joubert G, et al. CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury. Cmaj. 2010;182(4):341–8.
Ashwal S, Tong KA, Ghosh N, Bartnik-Olson B, Holshouser BA. Application of advanced neuroimaging modalities in pediatric traumatic brain injury. J Child Neurol. 2014;29(12):1704–17.
Langdon R, Taraman S. Posttraumatic Headache. Pediatr Ann. 2018;47(2):e61–e8.
Watanabe TK, Bell KR, Walker WC, Schomer K. Systematic review of interventions for post-traumatic headache. Pm r. 2012;4(2):129–40.
Eisenberg MA, Meehan WP 3rd, Mannix R. Duration and course of post-concussive symptoms. Pediatrics. 2014;133(6):999–1006.
Hu XH, Markson LE, Lipton RB, Stewart WF, Berger ML. Burden of migraine in the United States: disability and economic costs. Arch Intern Med. 1999;159(8):813–8.
Pearson R, Levyim D, Choe M, Taraman S, Langdon R. Survey of Child Neurologists on Management of Pediatric Post-traumatic Headache. J Child Neurol. 2019;34(12):739–47 Survey of management practices of pediatric post-traumatic headache among child neurologists.
Szperka CL, VanderPluym J, Orr SL, Oakley CB, Qubty W, Patniyot I, et al. Recommendations on the Use of Anti-CGRP Monoclonal Antibodies in Children and Adolescents. Headache. 2018;58(10):1658–69.
Seeger TA, Orr S, Bodell L, Lockyer L, Rajapakse T, Barlow KM. Occipital Nerve Blocks for Pediatric Posttraumatic Headache: A Case Series. J Child Neurol. 2015;30(9):1142–6.
Kroon Van Diest AM, Powers SW. Cognitive Behavioral Therapy for Pediatric Headache and Migraine: Why to Prescribe and What New Research Is Critical for Advancing Integrated Biobehavioral Care. Headache. 2019;59(2):289–97.
Blume HK, Brockman LN, Breuner CC. Biofeedback therapy for pediatric headache: factors associated with response. Headache. 2012;52(9):1377–86.
Lumba-Brown A, Yeates KO, Sarmiento K, Breiding MJ, Haegerich TM, Gioia GA, et al. Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children. JAMA Pediatr. 2018;172(11):e182853.
Irwin SL, Kacperski J, Rastogi RG. Pediatric Post-Traumatic Headache and Implications for Return to Sport: A Narrative Review. Headache. 2020;60(6):1076–92.
Halstead ME, McAvoy K, Devore CD, Carl R, Lee M, Logan K. Returning to learning following a concussion. Pediatrics. 2013;132(5):948–57 An important introduction of returning to learn following concussion in children.
TBI-related Emergency Department Visits, Hospitalizations, and Deaths (EDHDs) 2021 [Traumatic Brain Injury and Concussion webpage]. Available from: https://www.cdc.gov/traumaticbraininjury/data/tbi-edhd.html.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Michael Sowell, Paul Gong, and Lauren Evanczyk declare that they have no conflict of interest. Elizabeth Doll reports performing clinical research with fremanezumab in the pediatric population.
Human and Animal Rights and Informed Consent
All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki Declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Concussion and Head Injury
Rights and permissions
About this article
Cite this article
Doll, E., Gong, P., Sowell, M. et al. Post-traumatic Headache in Children and Adolescents. Curr Pain Headache Rep 25, 51 (2021). https://doi.org/10.1007/s11916-021-00967-y
Accepted:
Published:
DOI: https://doi.org/10.1007/s11916-021-00967-y