A new phase I clinical trial has demonstrated that belzutifan provides a route to sustained inhibition of hypoxia-inducible factor 2α in humans that is well tolerated and could be useful in the treatment of advanced clear cell kidney cancer.
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Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
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Acknowledgements
P.H.M. acknowledges the support of the Wellcome Trust (no. 19710), the NIHR Cambridge Biomedical Research Centre and the Rosetrees Trust (no. G102721).
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P.H.M. is a scientific founder and equity holder of ReOx Ltd and has received speaker honoraria from Fibrogen and Astellas. He has also undertaken consultancy work for Mission Therapeutics. N.B. declares no competing interests.
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Burrows, N., Maxwell, P.H. Hypoxia-inducible factor 2 inhibitors show promise in advanced kidney cancer. Nat Rev Urol 18, 516–517 (2021). https://doi.org/10.1038/s41585-021-00487-9
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DOI: https://doi.org/10.1038/s41585-021-00487-9
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