Selective molecular transport across the protein shells of bacterial microcompartments
Section snippets
Unanswered questions about molecular transport across MCP shells
There are a number of puzzling questions surrounding molecular transport across MCP shells. As mentioned above, there is compelling evidence that the shell of the Pdu MCP restricts the outward diffusion of propionaldehyde. However, at the same time, the substrates and products of the Pdu MCP (1,2-propanediol, propionyl-phosphate and 1-propanol) must be efficiently transported across the shell and the lumen enzymes must be supplied with required cofactors: NAD+, NADH, FAD, ATP, HS-CoA and
Conflict of interest statement
Nothing declared.
Acknowledgement
This work was supported by grant AI081146 from the National Institutes of Health to T.A.B.
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